| Company Name: |
SPIRO PHARMA |
| Tel: |
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| Email: |
eric_feng1954@126.com |
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| Product Name: | S-3013 | | Synonyms: | A-002;S-3013;Acetic acid, 2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-, methyl ester;inhibit,Phospholipase,Inhibitor,A002,Varespladib methyl,LY 333013,LY-333013,A 002;methyl 2-((3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-indol-4-yl)oxy)acetate;VARESPLADIB METHYL (LY333013);Varespladib methyl, 10 mM in DMSO;Varespladib Methyl | | CAS: | 172733-08-3 | | MF: | C22H22N2O5 | | MW: | 394.42 | | EINECS: | | | Product Categories: | | | Mol File: | 172733-08-3.mol |  |
| | S-3013 Chemical Properties |
| Melting point | 172-187 °C | | Boiling point | 624.6±65.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 100 mg/mL (253.54 mM) | | form | Solid | | pka | 12+-.0.50(Predicted) | | color | White to off-white |
| | S-3013 Usage And Synthesis |
| Uses | Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2). | | Definition | ChEBI: Varespladib methyl is a methyl ester resulting from the formal condensation of the carboxy group of varespladib with methanol. It is a potential therapy for the treatment of snakebite envenomings in which toxicity depends on the action of PLA2s. It has a role as a prodrug, an anti-inflammatory drug, an antidote and an EC 3.1.1.4 (phospholipase A2) inhibitor. It is a methyl ester, an aromatic ether, a member of benzenes, a member of indoles and a primary carboxamide. It is functionally related to a varespladib. | | References | [1] Bradley JD, et al. A randomized, double-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis. J Rheumatol. 2005 Mar;32(3):417-23. PMID:15742431
[2] Lewin M, et al. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. Toxins (Basel). 2016 Aug 25;8(9). pii: E248. DOI:10.3390/toxins8090248 |
| | S-3013 Preparation Products And Raw materials |
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