W4275

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W4275 Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:W4275
CAS:3051650-00-8
Purity:98% Package:1g
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:W4275
CAS:3051650-00-8
Package:50mg/RMB 16600
W4275 Basic information
Product Name:W4275
Synonyms:W4275;2-Quinazolinecarbonitrile, 6-methoxy-4-[[1-(1-methylethyl)-4-piperidinyl]amino]-7-[3-(4-morpholinyl)propoxy]-
CAS:3051650-00-8
MF:C25H36N6O3
MW:468.59
EINECS:
Product Categories:
Mol File:3051650-00-8.mol
W4275 Structure
W4275 Chemical Properties
Boiling point 659.2±65.0 °C(predicted)
density 1.23±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka9.51±0.50(predicted)
Safety Information
MSDS Information
W4275 Usage And Synthesis
UsesW4275 (Compound 42) is a selective NSD2 inhibitor with oral activity, showing an IC50 value of 17 nM. W4275 exhibits antiproliferative activity with an IC50 of 230 nM against RS411 cells and significantly inhibits tumor growth in the RS411 tumor xenograft model. Pharmacokinetic analysis in mice demonstrates that W4275 has good oral bioavailability (F of 27.34%). W4275 holds promise for use in cancer research[1].
IC 50NSD2: 17 nM (IC50)
References[1] Wei J, et al. Discovery of a Highly Potent and Selective Inhibitor Targeting Protein Lysine Methyltransferase NSD2. J Med Chem. 2024 Sep 4. DOI:10.1021/acs.jmedchem.4c00639
W4275 Preparation Products And Raw materials
Tag:W4275(3051650-00-8) Related Product Information
W4275 UNC0638 W4022 UNC 0638 MS0124 2-Cyclohexyl-6-methoxy-N-methyl-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine