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| | M871 (trifluoroacetate salt) Basic information |
| | M871 (trifluoroacetate salt) Chemical Properties |
| solubility | DMSO: Soluble: =10 mg/ml
Ethanol: Slightly Soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly Soluble: 0.1-1 mg/ml |
| | M871 (trifluoroacetate salt) Usage And Synthesis |
| Description | M871 is a peptide antagonist of galanin-2 (GAL2) receptors (Ki = 13.1 nM).1 It is selective for GAL2 receptors over GAL1 receptors (Ki = 420 nM). M871 (0.1, 1, or 10 nM) inhibits galanin-induced increases in inositol levels in CHO cells expressing human GAL2 receptors. It increases blood glucose, IL-8, IL-6, IL-22, and Tnf-α levels and decreases skeletal muscle and adipocyte glucose transporter 4 (Glut4) and peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc-1α) levels in a rat model of diabetes induced by a high-fat diet and streptozotocin (STZ; Item No. 13104) when administered intracerebroventricularly.2WARNING This product is not for human or veterinary use. | | References | [1] U. SOLLENBERG. M871—A Novel Peptide Antagonist Selectively Recognizing the Galanin Receptor Type 2[J]. International Journal of Peptide Research and Therapeutics, 2006, 12 1: 115-119. DOI: 10.1007/s10989-005-9008-x
[2] PENGHUA FANG . Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats[J]. Biochemical pharmacology, 2018, 156: Pages 241-247. DOI: 10.1016/j.bcp.2018.08.036 |
| | M871 (trifluoroacetate salt) Preparation Products And Raw materials |
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