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| | 4-Pyridinamine, 3-methyl-5-nitro- Basic information |
| Product Name: | 4-Pyridinamine, 3-methyl-5-nitro- | | Synonyms: | 4-AMino-3-Methyl-5-nitropyridine;3-Methyl-5-nitropyridin-4-aMine;3-Methyl-5-nitro-4-pyridinamine;4-Pyridinamine, 3-methyl-5-nitro-;4-Amino-5-methyl-3-nitropyridine;4-Amino-5-methyl-3-nitropyridine 97%;4-Pyridinamine, 3-methyl-5-nitro- ISO 9001：2015 REACH | | CAS: | 18227-67-3 | | MF: | C6H7N3O2 | | MW: | 153.14 | | EINECS: | | | Product Categories: | | | Mol File: | 18227-67-3.mol |  |
| | 4-Pyridinamine, 3-methyl-5-nitro- Chemical Properties |
| Melting point | 193 °C(Solv: water (7732-18-5)) | | Boiling point | 362.7±37.0 °C(Predicted) | | density | 1.354±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 5.25±0.24(Predicted) | | Appearance | Light yellow to green yellow Solid |
| | 4-Pyridinamine, 3-methyl-5-nitro- Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-amino-5-methyl-3-nitropyridine from 3-methyl-4-aminopyridine: 4-amino-3-methylpyridine (3.00 g) was dissolved in ice-cold concentrated sulfuric acid (36 mL). Subsequently, fuming nitric acid (4.72 g) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 1 hour, then warmed to 60°C and heated continuously for 14 hours. Upon completion of the reaction, it was cooled to ambient temperature, the reaction mixture was slowly poured into ice water and the pH of the solution was adjusted to 13 with solid KOH. The precipitate was collected by filtration, washed with water and dried to afford the target product 4-amino-3-methyl-5-nitropyridine in a yield of 1.198 g (31.3% yield). | | References | [1] Patent: WO2005/63744, 2005, A2. Location in patent: Page/Page column 232
[2] Nucleosides, Nucleotides and Nucleic Acids, 2002, vol. 21, # 11-12, p. 737 - 751 |
| | 4-Pyridinamine, 3-methyl-5-nitro- Preparation Products And Raw materials |
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