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| | 2,4-Dichlorophenylacetonitrile Basic information |
| Product Name: | 2,4-Dichlorophenylacetonitrile | | Synonyms: | 2,4-DICHLOROPHENYLACETONITRILE;2,4-DCCN;2,4-Dichlorobenzeneacetonitrile;Acetonitrile, (2,4-dichlorophenyl)-;2,4-dichloro cyanobenzene;2,4-Dichlorophenylacetonitrile,98%;(2,4-Dichlorphenyl)acetonitril;2,4-DICHLOROPHENYLACETONITRILE / 2,4-DICHLOROBENZYL CYANIDE | | CAS: | 6306-60-1 | | MF: | C8H5Cl2N | | MW: | 186.04 | | EINECS: | 228-621-4 | | Product Categories: | Building Blocks;C8 to C9;Chemical Synthesis;Cyanides/Nitriles;Nitrogen Compounds;Organic Building Blocks;Aromatic Phenylacetic Acids and Derivatives;Nitrile | | Mol File: | 6306-60-1.mol |  |
| | 2,4-Dichlorophenylacetonitrile Chemical Properties |
| Melting point | 58-61 °C (lit.) | | Boiling point | 306.06°C (rough estimate) | | density | 1.4274 (rough estimate) | | refractive index | 1.5690 (estimate) | | Fp | 176 °C | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | color | White to Light yellow to Light orange | | BRN | 2047688 | | Exposure limits | NIOSH: IDLH 25 mg/m3 | | InChI | 1S/C8H5Cl2N/c9-7-2-1-6(3-4-11)8(10)5-7/h1-2,5H,3H2 | | InChIKey | VJARIBGMDPJLCL-UHFFFAOYSA-N | | SMILES | Clc1ccc(CC#N)c(Cl)c1 | | CAS DataBase Reference | 6306-60-1(CAS DataBase Reference) | | NIST Chemistry Reference | Benzeneacetonitrile, 2,4-dichloro-(6306-60-1) | | EPA Substance Registry System | (2,4-Dichlorophenyl)acetonitrile (6306-60-1) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-20/21/22 | | Safety Statements | 26-36/37/39 | | RIDADR | 3276 | | WGK Germany | 1 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29269090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2,4-Dichlorophenylacetonitrile Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | 2,4-Dichlorophenylacetonitrile was used in the synthesis of 2,4-dichloromandelic acid. | | Synthesis | General method: 2,4-dichlorobenzyl chloride (1.0 mmol) was mixed with sodium cyanide (2 mmol) in deionized water (5 mL) and polyethylene glycol modified diisocyanate (PEG-MDIL, 0.2 g) was added. The reaction suspension was placed under reflux conditions and the reaction mixture was stirred using a magnetic stirrer for the reaction time referred to in Table 2.After completion of the reaction, the mixture was extracted with ether (2 × 10 mL). The organic extracts were combined, dried with anhydrous calcium chloride and subsequently concentrated under reduced pressure. By this method, the target product 2,4-dichlorophenylacetonitrile was obtained in good to excellent isolated yields (see Scheme 3). | | References | [1] Organic Preparations and Procedures International, 2011, vol. 43, # 3, p. 285 - 291
[2] Journal of Molecular Liquids, 2015, vol. 202, p. 34 - 39
[3] Journal of Molecular Catalysis A: Chemical, 2012, vol. 365, p. 80 - 86
[4] Applied Organometallic Chemistry, 2018, vol. 32, # 2,
[5] Catalysis Communications, 2012, vol. 18, p. 102 - 105 |
| | 2,4-Dichlorophenylacetonitrile Preparation Products And Raw materials |
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