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| | Isoquinoline-5-boronic acid Basic information |
| | Isoquinoline-5-boronic acid Chemical Properties |
| Melting point | 204-206 | | Boiling point | 419.1±37.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | form | solid | | pka | 7.70±0.30(Predicted) | | color | Off white to light yellow | | InChIKey | XKEYHBLSCGBBGU-UHFFFAOYSA-N | | CAS DataBase Reference | 371766-08-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant/Keep Cold | | HazardClass | IRRITANT | | HS Code | 2933499090 |
| | Isoquinoline-5-boronic acid Usage And Synthesis |
| Uses | Isoquinoline-5-boronic acid, HCl | | Synthesis | To a solution of 5-bromoisoquinoline (1.46 g, 7.0 mmol) in THF (20 mL) prepared according to the literature method (Brown, W. D et al., Synthesis 2002, 83), triisopropyl borate (2.4 mL, 10.5 mmol) and tertiary-butyllithium (1.7 M, 9.5 mL) were sequentially added at -78 °C. The reaction mixture was slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched with 1N HCl (10 mL) and a solid product was obtained after decantation of the THF layer. The solid was identified as 5-isoquinolineboronic acid (1.0 g, 82% yield). The mass spectrum (ESI) showed the (M + 1) peak as 174.12. | | References | [1] Patent: WO2005/72732, 2005, A1. Location in patent: Page/Page column 61
[2] Patent: WO2008/6480, 2008, A1. Location in patent: Page/Page column 5-6 |
| | Isoquinoline-5-boronic acid Preparation Products And Raw materials |
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