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| | 3-Bromo-2-hydroxy-5-methylpyridine Basic information |
| | 3-Bromo-2-hydroxy-5-methylpyridine Chemical Properties |
| Melting point | 78-82 °C (lit.) | | Boiling point | 324.0±42.0 °C(Predicted) | | density | 1.622±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 10.95±0.10(Predicted) | | form | powder to crystal | | color | White to Orange to Green | | BRN | 1423374 | | InChI | 1S/C6H6BrNO/c1-4-2-5(7)6(9)8-3-4/h2-3H,1H3,(H,8,9) | | InChIKey | KHBRMXVUQOVORD-UHFFFAOYSA-N | | SMILES | Cc1cnc(O)c(Br)c1 | | CAS DataBase Reference | 17282-02-9(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-37/38-41-36/37/38 | | Safety Statements | 26-36/37/39-36 | | RIDADR | 1993 | | WGK Germany | 3 | | Hazard Note | Irritant/Keep Cold | | PackingGroup | III | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 3-Bromo-2-hydroxy-5-methylpyridine Usage And Synthesis |
| Chemical Properties | White solid | | Synthesis | 5-Methylpyridin-2-ol (1 g, 9.16 mmol) was used as starting material and dissolved in 4 mL of carbon disulfide (CS2). Bromine (Br2, 0.47 mL) was slowly added to this solution at room temperature and the reaction mixture was stirred for 2 hours. Upon completion of the reaction, aqueous sodium thiosulfate (Na2S2O3) was added to quench the reaction, followed by extraction of the reaction mixture with ethyl acetate (EtOAc). The organic layer was separated, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to afford the solid product 3-bromo-2-hydroxy-5-methylpyridine (1.7 g, 98% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ 7.73 (1H, s), 7.22 (1H, s), 2.10 (3H, s). | | References | [1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0168
[2] Patent: US2008/85906, 2008, A1. Location in patent: Page/Page column 15 |
| | 3-Bromo-2-hydroxy-5-methylpyridine Preparation Products And Raw materials |
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