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| | L-N5-(1-Iminopropyl) ornithine (hydrochloride) Basic information |
| | L-N5-(1-Iminopropyl) ornithine (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid |
| | L-N5-(1-Iminopropyl) ornithine (hydrochloride) Usage And Synthesis |
| Description | Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to nitric oxide (NO) and citrulline. Methyl-L-NIO (hydrochloride) is a competitive nitric oxide synthase (NOS) inhibitor that competes with L-arginine for the amino acid binding site. It is a more potent inhibitor of nNOS (Ki = 3.0 μM) than eNOS (Ki = 10.0 μM) or iNOS (Ki = 9.5 μM). | | Uses | Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 μM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 μM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively; the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS)[1]. | | References | [1] Kotthaus J, et al. Structure–activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads[J]. Bioorganic & medicinal chemistry, 2008, 16(24): 10205-10209. |
| | L-N5-(1-Iminopropyl) ornithine (hydrochloride) Preparation Products And Raw materials |
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