Ethyl-L-NiO (hydrochloride)

Request For Quotation
Ethyl-L-NiO (hydrochloride) Suppliers list
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: BOC Sciences  
Tel: 16314854226; +8616314854226
Email: inquiry@bocsci.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: MedBioPharmaceutical Technology Inc  
Tel: 021-69568360 18916172912
Email: order@med-bio.cn

Ethyl-L-NiO (hydrochloride) manufacturers
Ethyl-L-NiO (hydrochloride) Basic information
Product Name:Ethyl-L-NiO (hydrochloride)
Synonyms:L-N5-(1-IMINOBUTYL)ORNITHINE HYDROCHLORIDE;DWNWLIPSWIUXRG-FJXQXJEOSA-N;chloro (2S)-2-amino-5-(1-aminobutylideneamino)pentanoate;EthylLNIO (hydrochloride),Ethyl L NIO (hydrochloride);L-Ornithine, N5-(1-iminobutyl)-, monohydrochloride (9CI);Ethyl-L-NiO (hydrochloride)
CAS:150403-97-7
MF:C9H18ClN3O2
MW:0
EINECS:
Product Categories:
Mol File:150403-97-7.mol
Ethyl-L-NiO (hydrochloride) Structure
Ethyl-L-NiO (hydrochloride) Chemical Properties
storage temp. Store at -20°C
solubility DMF: 0.3 mg/ml; DMSO: 2 mg/ml; Ethanol: 2.5 mg/ml; PBS (pH 7.2): 5 mg/ml
form A crystalline solid
Safety Information
MSDS Information
Ethyl-L-NiO (hydrochloride) Usage And Synthesis
DescriptionEthyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 μM, respectively, as determined using initial rate measurements. However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 μM, respectively). Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.
UsesEthyl-L-NIO hydrochloride is a potent and competitive human dimethylarginine dimethylaminohydrolase 1 (hDDAH-1) inhibitor with an IC50 of 70 μM and a Ki of 32 μM[1].
References[1] Kotthaus J, et al. Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DOI:10.1016/j.bmc.2008.10.058
Ethyl-L-NiO (hydrochloride) Preparation Products And Raw materials
Tag:Ethyl-L-NiO (hydrochloride)(150403-97-7) Related Product Information
L(+)-Ornithine hydrochloride L-NiO dihydrochloride L-N5-(1-Iminopropyl) ornithine (hydrochloride) Ethyl-L-NiO (hydrochloride) Ng-monomethyl-L-arginine acetate Propenyl-L-NIO (hydrochloride)