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| | OlMesartan MedoxoMil-d6 Basic information |
| | OlMesartan MedoxoMil-d6 Chemical Properties |
| Melting point | >75°C (dec.) | | Boiling point | 804.229±75.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.384±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 4.154±0.10(predicted) | | color | White to Off-White |
| | OlMesartan MedoxoMil-d6 Usage And Synthesis |
| Description | Olmesartan medoxomil-d6 is intended for use as an internal standard for the quantification of olmesartan medoxomil by GC- or LC-MS. Olmesartan medoxomil is an orally bioavailable prodrug form of olmesartan , a nonpeptide angiotensin II antagonist that is selective for the angiotensin 1 (AT1) receptor over the AT2 receptor. Olmesartan medoxomil (0.1 mg/kg) inhibits the angiotensin II pressor response in normotensive rats. It reduces both systolic and diastolic blood pressure in fructose-fed rats, a model of insulin resistance, when administered at a dose of 10 mg/kg per day, as well as in chow-fed control animals when administered at a dose of 11.4 mg/kg per day. Olmesartan medoxomil also inhibits increases in plasma levels of triglycerides and non-esterified fatty acids in fructose-fed rats. Formulations containing olmesartan medoxomil have been used in the treatment of hypertension. | | Chemical Properties | White to Off-White Solid | | Uses | Labelled Olmesartan Medoxomil (O550000). Olmesartan Medoxomil is an angiotensin II receptor antagonist. Olmesartan Medoxomil is used as an anti-hypertensive. | | Uses | A labelled angiotensin II receptor antagonist. Used as an anti-hypertensive. | | Uses | OlMesartan MedoxoMil-d6 is an angiotensin II receptor antagonist,it is used as an anti-hypertensive. | | IC 50 | AT1 Receptor | | References | [1] MAKOTO MIZUNO . Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist[J]. European journal of pharmacology, 1995, 285 2: Pages 181-188. DOI: 10.1016/0014-2999(95)00401-6
[2] KENTA OKADA. Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats.[J]. Hypertension Research, 2004, 27 4: 293-299. DOI: 10.1291/hypres.27.293 |
| | OlMesartan MedoxoMil-d6 Preparation Products And Raw materials |
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