- Trityl olmesartan
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2026-09-11
- CAS:144690-92-6
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 1000kg
- Trityl olmesartan
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- $1.10
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2026-08-20
- CAS:144690-92-6
- Min. Order: 1g
- Purity: 99.0% Min
- Supply Ability: 100 Tons
- Trityl olmesartan
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-
2026-06-30
- CAS:144690-92-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
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| | Trityl olmesartan Basic information |
| | Trityl olmesartan Chemical Properties |
| Melting point | 104-106°C | | Boiling point | 960.0±75.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMF: 1 mg/ml,DMSO: 1 mg/ml | | pka | 13.21±0.29(Predicted) | | form | A solid | | Appearance | White to off-white Solid | | InChIKey | IJOPLMOXIPGJIJ-UHFFFAOYSA-N | | SMILES | C1(CCC)N(CC2=CC=C(C3=CC=CC=C3C3N(C(C4=CC=CC=C4)(C4=CC=CC=C4)C4=CC=CC=C4)N=NN=3)C=C2)C(C(OCC2=C(C)OC(=O)O2)=O)=C(C(O)(C)C)N=1 | | CAS DataBase Reference | 144690-92-6(CAS DataBase Reference) |
| | Trityl olmesartan Usage And Synthesis |
| Chemical Properties | Off-White to White Powder | | Uses | Olmesartan medoxomil analog as angiotensin II antagonist. | | Uses | Olmesartan medoxomil intermediate. | | Uses | N-1 Trityl Olmesartan Medoxomil (Olmesartan EP Impurity D) is an olmesartan medoxomil intermediate. | | Synthesis | This describes steps for preparing a trityl-protected intermediate in olmesartan medoxomil synthesis:
1. An imidazole ester derivative is alkylated with a trityl-protected biphenyltetrazole bromide in acetone with KCO/phase-transfer catalyst. Work-up gives an intermediate.
2. This intermediate is further alkylated with a side-chain bromide in the presence of acetone/KCO/KI. Treatment with toluene/methanol precipitates trityl olmesartan ester. |
| | Trityl olmesartan Preparation Products And Raw materials |
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