Trityl olmesartan

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CAS:144690-92-6
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CAS:144690-92-6
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Products Intro: Product Name:Triphenyl Methyl Olmesartan
CAS:144690-92-6
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CAS:144690-92-6
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CAS:144690-92-6

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  • 2026-04-03
  • CAS:144690-92-6
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  • 2026-03-20
  • CAS:144690-92-6
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Trityl olmesartan Basic information
Product Name:Trityl olmesartan
Synonyms:Trityl olmesartan;5-Methoxy – 2-oxo-1,3-dioxol - 4 - yl ) methyl - 4 - (1-hydroxy -1 - methylethyl -2 propyl-1- (2 –(2-triphenylmethyl ) -2H – tetrazole -5 – yl ) biphenyl -4-yl ) methyl ) -1H-imidazole – 5 – carboxylate;TRIPHENYL METHYL OLMESARTAN;OMSTint-G;Olmesartan USP Impurity D;3-((3'-carbamoyl-[1,1'-biphenyl]-3-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid;Olmesartan Medoxomil impurity 13/ N1-Trityl Olmesartan Medoxomil/(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(prop-1-en-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate;Olmesartan Medoxomil-4
CAS:144690-92-6
MF:C48H44N6O6
MW:800.9
EINECS:604-437-3
Product Categories:INTERMEDIATESOF;(intermediate of olmesartan);Bases & Related Reagents;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;LFQ
Mol File:144690-92-6.mol
Trityl olmesartan Structure
Trityl olmesartan Chemical Properties
Melting point 104-106°C
Boiling point 960.0±75.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMF: 1 mg/ml,DMSO: 1 mg/ml
pka13.21±0.29(Predicted)
form A solid
AppearanceWhite to off-white Solid
InChIKeyIJOPLMOXIPGJIJ-UHFFFAOYSA-N
SMILESC1(CCC)N(CC2=CC=C(C3=CC=CC=C3C3N(C(C4=CC=CC=C4)(C4=CC=CC=C4)C4=CC=CC=C4)N=NN=3)C=C2)C(C(OCC2=C(C)OC(=O)O2)=O)=C(C(O)(C)C)N=1
CAS DataBase Reference144690-92-6(CAS DataBase Reference)
Safety Information
MSDS Information
Trityl olmesartan Usage And Synthesis
Chemical PropertiesOff-White to White Powder
UsesOlmesartan medoxomil analog as angiotensin II antagonist.
UsesOlmesartan medoxomil intermediate.
UsesN-1 Trityl Olmesartan Medoxomil (Olmesartan EP Impurity D) is an olmesartan medoxomil intermediate.
SynthesisThis describes steps for preparing a trityl-protected intermediate in olmesartan medoxomil synthesis:
1. An imidazole ester derivative is alkylated with a trityl-protected biphenyltetrazole bromide in acetone with KCO/phase-transfer catalyst. Work-up gives an intermediate.
2. This intermediate is further alkylated with a side-chain bromide in the presence of acetone/KCO/KI. Treatment with toluene/methanol precipitates trityl olmesartan ester.
Tag:Trityl olmesartan(144690-92-6) Related Product Information
Triphenylbismuth OlMesartan interMediate iMpurity II 3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one Olmesartan medoxomil impurity I diethyl 2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate OlMesartan MedoxoMil iMpurity V N-Trityl Olmesartan Ethyl Ester Trityl olMesartan MedoxoMil iMpurity III Olmesartan Triphenylphosphine 5-(HYDROXYMETHYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER Trityl olmesartan 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate 4-HYDROXYMETHYL-1,3-DIOXOLAN-2-ONE Olmesartan N-TRITYL OLMESARTAN-D6 ETHYL ESTER 4-ISOPROPYL-2-METHYLIMIDAZOLE