- DIHYDROFISETIN
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- $29.00 / 100KG
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2019-07-06
- CAS:20725-03-5
- Min. Order: 10KG
- Purity: 99%
- Supply Ability: 10000kg
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| | DIHYDROFISETIN Basic information |
| Product Name: | DIHYDROFISETIN | | Synonyms: | DIHYDROFISETIN;3,3',4',7-TETRAHYDROXYFLAVANONE;3',4',7-TRIHYDROXYFLAVANONOL;2,3-DIHYDROFISETH;2,3-DIHYDROFISETIN;3,3,4,7-TETRAHYDROXYFLAVANONE 97%;3,7,3'',4''-TETRAHYDROXYFLAVANONE WITH HPLC;5-Deoxydihydrouercetin | | CAS: | 20725-03-5 | | MF: | C15H12O6 | | MW: | 288.25 | | EINECS: | 243-989-6 | | Product Categories: | Dihydro-Flavanols | | Mol File: | 20725-03-5.mol |  |
| | DIHYDROFISETIN Chemical Properties |
| Melting point | 216-217°C | | storage temp. | -20°C | | solubility | Acetone: soluble,Chloroform: soluble,Dichloromethane: soluble,DMSO: soluble,Ethyl Acetate: soluble | | form | A solid | | Boiling point | 644.2±55.0 °C(Predicted) | | density | 1.599±0.06 g/cm3(Predicted) | | pKa | 7.59±0.60(Predicted) | | color | White to off-white | | LogP | 0.870 |
| | DIHYDROFISETIN Usage And Synthesis |
| Uses | Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1]. | | Definition | ChEBI: A dihydroflavonol that is the 2,3-dihydro derivative of fisetin. | | in vivo | Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice[1]. | Animal Model: | Aβ-treated C57BL/6 mice[1] | | Dosage: | 50 and 100 mg/kg | | Administration: | Oral administration;daily, for 11days | | Result: | Decreased freezing response in Aβ-treated C57BL/6 mice. |
| Animal Model: | Aβ-treated C57BL/6 mice[1] | | Dosage: | 50 and 100 mg/kg | | Administration: | Oral administration;daily, for 11days | | Result: | Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity. |
| Animal Model: | Aβ-treated C57BL/6 mice[1] | | Dosage: | 50 and 100 mg/kg | | Administration: | Oral administration;daily, for 11days | | Result: | Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB. |
| | References | [1] Jin CH, et, al. Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. J Neurosci Res. 2009 Dec;87(16):3658-70. DOI:10.1002/jnr.22159 |
| | DIHYDROFISETIN Preparation Products And Raw materials |
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