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| | D-myo-Inositol-2,4,5-triphosphate (sodium salt) Basic information |
| | D-myo-Inositol-2,4,5-triphosphate (sodium salt) Chemical Properties |
| | D-myo-Inositol-2,4,5-triphosphate (sodium salt) Usage And Synthesis |
| Description | The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals.1,2 The most studied InsP, D-myo-Inositol-2,4,5-triphosphate (sodium salt) (Ins(1,4,5)P3), more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3,4 Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4,5 Ins(2,4,5)P3 is a metabolically stable analog of Ins(1,4,5)P3 that is commonly used to study Ca2+ signaling pathways. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3.6WARNING This product is not for human or veterinary use. |
| | D-myo-Inositol-2,4,5-triphosphate (sodium salt) Preparation Products And Raw materials |
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