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| | D-myo-Inositol-3,4,5-triphosphate (sodium salt) Basic information |
| | D-myo-Inositol-3,4,5-triphosphate (sodium salt) Chemical Properties |
| solubility | Water: 50 mg/ml |
| | D-myo-Inositol-3,4,5-triphosphate (sodium salt) Usage And Synthesis |
| Description | D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)-P3) is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate.1,2 Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum in opening of the calcium channels and an increase in intracellular calcium.2,3 D-myo-Inositol-3,4,5-triphosphate (Ins(3,4,5)-P3) is a structural analog of Ins(1,4,5)-P3 and a member of the inositol phosphate (InsP) cell signaling family of molecules.4,5 D-myo Ins(3,4,5)-P3 is 200-fold less potent than D-myo Ins(1,4,5)-P3 at initiating Ca++ release when injected into Xenopus oocytes.6 Ins(1,4,5)-P3 binds to Type 1, 2, and 3 subtypes of the rat recombinant IP3 receptor with Ki values of less than 25 nM, whereas Ins(3,4,5)-P3 exhibits significantly lower affinity with Ki values of 3-11 µM.7WARNING This product is not for human or veterinary use. | | References | [1] H. STREB. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate[J]. Nature, 1983, 306 5938: 67-69. DOI: 10.1038/306067a0
[2] Y YOSHIDA S I. Structure and function of inositol 1,4,5-trisphosphate receptor.[J]. Japanese journal of pharmacology, 1997, 74 2: 125-137. DOI: 10.1254/jjp.74.125
[3] EXTON J H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins.[J]. Annual review of pharmacology and toxicology, 1996, 36: 481-509. DOI: 10.1146/annurev.pa.36.040196.002405
[4] BERRIDGE M J. Inositol trisphosphate and calcium signalling[J]. Nature, 1993, 361 6410: 315-325. DOI: 10.1038/361315a0
[5] MAJERUS P W. Inositol phosphate biochemistry.[J]. Annual review of biochemistry, 1992, 61: 225-250. DOI: 10.1146/annurev.bi.61.070192.001301
[6] S DELISLE. Second messenger specificity of the inositol trisphosphate receptor: reappraisal based on novel inositol phosphates.[J]. American Journal of Physiology, 1994, 266 2 Pt 1: C429-36. DOI: 10.1152/ajpcell.1994.266.2.c429
[7] E. NEROU. Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor.[J]. The Ukrainian Biochemical Journal, 2001, 22 1: 59-69. DOI: 10.1042/bj3550059 |
| | D-myo-Inositol-3,4,5-triphosphate (sodium salt) Preparation Products And Raw materials |
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