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| | 1d-Myo-inositol-1,3,4-triphosphate, (Na+ salt) Basic information |
| Product Name: | 1d-Myo-inositol-1,3,4-triphosphate, (Na+ salt) | | Synonyms: | 1D-MYO-INOSITOL-2,4,5-TRISPHOSPHATE, (NA+ SALT);D-MYO-INOSITOL-1,3,4-TRIPHOSPHATE SODIUM SALT;D-MYO-INOSITOL-1,3,4-TRIS(DIHYDROGEN PHOSPHATE), HEXASODIUM SALT;INS(1,3,4)P3 (NA+ SALT);INS(2,4,5)P3 (NA+ SALT);INS(1,3,4)IP3 (SODIUM SALT);D-myo-Inositol-1,3,4-trisphosphate sodium salt;1d-Myo-inositol-1,3,4-triphosphate, (Na+ salt) | | CAS: | | | MF: | C6H9Na6O15P3 | | MW: | 551.99 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 1d-Myo-inositol-1,3,4-triphosphate, (Na+ salt) Chemical Properties |
| solubility | PBS pH 7.2: >50 mg/ml (from D-myo-Inositol | | form | Lyophilized Powder | | color | White to off-white |
| | 1d-Myo-inositol-1,3,4-triphosphate, (Na+ salt) Usage And Synthesis |
| Description | D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels.1 The levels of Ins(1,3,4)-P3 are in turn regulated by the levels of cytosolic free calcium.2 The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.3WARNING This product is not for human or veterinary use. | | References | [1] X YANG. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate.[J]. The Journal of Biological Chemistry, 1999, 274 27: 18973-18980. DOI: 10.1074/jbc.274.27.18973
[2] P D LEW. The role of cytosolic free calcium in the generation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in HL-60 cells. Differential effects of chemotactic peptide receptor stimulation at distinct Ca2+ levels.[J]. The Journal of Biological Chemistry, 1986, 261 28: 13121-13127.
[3] Y YOSHIDA S I. Structure and function of inositol 1,4,5-trisphosphate receptor.[J]. Japanese journal of pharmacology, 1997, 74 2: 125-137. DOI: 10.1254/jjp.74.125 |
| | 1d-Myo-inositol-1,3,4-triphosphate, (Na+ salt) Preparation Products And Raw materials |
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