4-Ethynyl-L-phenylalanine HCl manufacturers
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| | 4-Ethynyl-L-phenylalanine HCl Basic information |
| Product Name: | 4-Ethynyl-L-phenylalanine HCl | | Synonyms: | L-Phenylalanine, 4-ethynyl-;4-Ethynyl-L-phenylalanine HCl;pEthynylphenylalanine,p Ethynylphenylalanine;(2S)-2-amino-3-(4-ethynylphenyl)propanoic acid;(S)-2-Amino-3-(4-ethynylphenyl)propanoic acid;p-Ethynylphenylalanine, 10 mM in DMSO;4-Ethynyl-L-phenylalanine;4-Ethynylphenylalanine | | CAS: | 278605-15-5 | | MF: | C11H11NO2 | | MW: | 189.21 | | EINECS: | | | Product Categories: | | | Mol File: | 278605-15-5.mol |  |
| | 4-Ethynyl-L-phenylalanine HCl Chemical Properties |
| Boiling point | 343.2±37.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 2.22 mg/mL (11.73 mM) | | form | Solid | | pka | 2.18±0.10(Predicted) | | color | Off-white to light yellow |
| | 4-Ethynyl-L-phenylalanine HCl Usage And Synthesis |
| Uses | p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | in vivo | p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1].
| Animal Model: | Male Sprague-Dawley rats (200 g)[1] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |
| | References | [1] Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73. DOI:10.1046/j.1471-4159.2000.0742067.x |
| | 4-Ethynyl-L-phenylalanine HCl Preparation Products And Raw materials |
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