- Verdinexor
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- $30.00
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2026-06-02
- CAS:1392136-43-4
- Purity: 98.00%
- Supply Ability: 10g
- Verdinexor (KPT-335)
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- $1.00
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2019-07-06
- CAS: 1392136-43-4
- Min. Order: 1G
- Purity: 98%
- Supply Ability: 100KG
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| | Verdinexor (KPT-335) Basic information |
| Product Name: | Verdinexor (KPT-335) | | Synonyms: | Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-;Verdinexor(KPT-335);(2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]- 2-propenoic acid-2-(2-pyridinyl)hydrazide;(2Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N -(pyridin-2-yl)prop-2-enehydrazide Verdinexor(KPT-335);(KPT335)(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)acrylohydrazide;CS-1798;(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide;KPT335(Verdinexor) | | CAS: | 1392136-43-4 | | MF: | C18H12F6N6O | | MW: | 442.32 | | EINECS: | | | Product Categories: | Inhibitors;API | | Mol File: | 1392136-43-4.mol |  |
| | Verdinexor (KPT-335) Chemical Properties |
| density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥44.2 mg/mL in DMSO; insoluble in H2O; ≥2.31 mg/mL in EtOH with ultrasonic | | form | solid | | pka | 10.04±0.43(Predicted) | | color | Light yellow to yellow | | InChI | InChI=1S/C18H12F6N6O/c19-17(20,21)12-7-11(8-13(9-12)18(22,23)24)16-26-10-30(29-16)6-4-15(31)28-27-14-3-1-2-5-25-14/h1-10H,(H,25,27)(H,28,31)/b6-4- | | InChIKey | OPAKEJZFFCECPN-XQRVVYSFSA-N | | SMILES | C(NNC1=NC=CC=C1)(=O)/C=C\N1C=NC(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=N1 | | CAS DataBase Reference | 1392136-43-4 |
| | Verdinexor (KPT-335) Usage And Synthesis |
| Uses | Verdinexor is a potent and selective SINE inhibitor, shown to be effective in treating influenza A virus infection in mice and ferret models. | | Biological Activity | verdinexor (kpt-335) is a potent and selective inhibitor of nuclear export [1].nuclear export (sine) is mainly mediated by exportin 1 (xpo1) and mediates specific proteins out of the nucleus, which plays an important role in the regulation of proliferation and the cell cycle [2].verdinexor (kpt-335) is a potent and selective sine inhibitor that acts as an antiviral drug. in a549 cells inoculated with the influenza a and b virus, verdinexor effectively inhibited the replication of the influenza a and b virus strains tested. verdinexor (1 μm) caused the accumulation of vrnps in the nuclei and altered the localization of viral ns1. also, verdinexor increased nuclear negative-sense vrna by 56.6-fold and significantly reduced cytoplasmic negative-sense vrna, which suggested that verdinexor blocked vrnp nuclear export. in 293t cells, verdinexor inhibited xpo1-nep binding [1].in mice infected with influenza virus a, verdinexor significantly reduced lung influenza virus a titers. verdinexor also reduced the expression of proinflammatory cytokines tumor necrosis factor alpha, interleukin-6, interleukin-1β and gamma interferon. in mice infected with a lethal dose, verdinexor inhibited virus penetration of the respiratory tract and virus spread in the lungs [1]. in companion dogs with b- and t-cell lymphomas, verdinexor showed potent cytotoxic activity [2]. | | Synthesis | Example 3: Synthesis of (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)acrylhydrazide hydrochloride (1-4). To a 500 mL three-necked round-bottomed flask was added a suspension of (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylhydrazide (10 g, 1.0 equiv) in 1:1 CH2Cl2:AcOEt (200 mL). 2-Hydrazinylpyridine (3.11 g) was added at -40 °C. T3P (50% ethyl acetate solution, 21.75 g) was added dropwise followed by DIPEA (7.36 g). The reaction mixture was stirred at -40 °C for 30 min and then concentrated under reduced pressure at 35 °C, 20 mmHg. A crude brown oil was obtained, which was purified by column chromatography (eluent: CH2Cl2 solution of 1.3% MeOH). The fractions containing the target compound were combined to give 6.0 g (yield: 48%) of (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)acrylhydrazide.1H NMR (400 MHz, DMSO-d6) δ: 10.41 (s, 1H), 9.66 (s, 1H) , 8.59 (s, 1H), 8.53 (s, 2H), 8.28 (s, 1H), 8.06-8.08 (d, J = 5.2 Hz, 1H), 7.48-7.53 (m, 1H), 7.49-7.52 (d, J = 10.4 Hz, 1H), 6.71-6.75 (m, 1H), 6.66-6.68 (d, J = 8.4 Hz, 1H), 6.07-6.09 (d, J = 10.4 Hz, 1H).LCMS (C18H12F6N6O [M+H]+) Predicted: 443.33, Measured: 443.44 (RT 2.45 min, purity: 100%). | | storage | Store at -20°C | | references | [1]. perwitasari o, johnson s, yan x, et al. verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo. j virol, 2014, 88(17): 10228-10243.
[2]. gravina gl, senapedis w, mccauley d, et al. nucleo-cytoplasmic transport as a therapeutic target of cancer. j hematol oncol, 2014, 7: 85. |
| | Verdinexor (KPT-335) Preparation Products And Raw materials |
| Raw materials | 3,5-Bis(trifluoromethyl)benzonitrile-->3,5-DI(TRIFLUOROMETHYL)BENZENE-1-CARBOTHIOAMIDE-->(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid-->3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole-->(Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate-->2-Hydrazinopyridine-->Dichloromethane-->Propylphosphonic anhydride-->Ethyl acetate-->N,N-Diisopropylethylamine |
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