- AZD1283
-
- $31.00 / 1mg
-
2026-01-08
- CAS:919351-41-0
- Min. Order:
- Purity: 99.621%
- Supply Ability: 10g
- AZD1283
-
- $1.00 / 1ASSAYS
-
2019-09-06
- CAS:919351-41-0
- Min. Order: 1ASSAYS
- Purity: 95%~99%
- Supply Ability: per week:100kg
|
| | AZD1283 Basic information |
| Product Name: | AZD1283 | | Synonyms: | ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate AZD1283;ETHYL 6-(4-{[(BENZYLSULFONYL)AMINO]CARBONYL}PIPERIDIN-1-YL)-5-CYANO-2-METHYLNICOTINATE;AZD1283 , CID23649325;AZD1283;6-[4-[[(Benzylsulfonyl)amino]carbonyl]piperidin-1-yl]-5-cyano-2-methylnicotinic acid ethyl ester;CS-1176;Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate;AZD-1283;AZD 1283 | | CAS: | 919351-41-0 | | MF: | C23H26N4O5S | | MW: | 470.54 | | EINECS: | | | Product Categories: | | | Mol File: | 919351-41-0.mol |  |
| | AZD1283 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | insoluble in H2O; insoluble in EtOH; ≥18.15 mg/mL in DMSO | | form | solid | | color | White to yellow |
| | AZD1283 Usage And Synthesis |
| Uses | AZD 1283 is a non-nucleotide reversible antagonist of P2Y12R, which regulates platelet activation and thrombus formation. | | Biological Activity | the central role of the p2y12 receptor in platelet function makes it an attractive target for the development of novel antiplatelet therapies. azd1283 is found to be a potent, selective and reversible antagonist of the p2y12 receptor. | | in vitro | it was observed that the benzylic azd1283 and its analogue 13 were both potent in the higher order residual platelet count assay in which the two tested 5-chlorothienyls showed low (ic50 >22 μm) potency [1]. | | in vivo | in a modified folts model in dog, both azd1283 and its analogue 13 could dose-dependently induce increases in blood flow and inhibition of adp-induced platelet aggregation with antithrombotic ed50 values of 3.0 and 10.0 μg/kg/min, respectively. the dose that induced a larger than 3-fold increase in bleeding time were 33 and 100 μg/kg/min for azd1283 and 13, respectively [2]. | | IC 50 | 0.011, 0.025 and 3.2 μm for binding, gtpγs and residual platelet count (rpc), respectively | | storage | Store at -20°C | | references | [1] bach p, antonsson t, bylund r, björkman ja, österlund k, giordanetto f, van giezen jj, andersen sm, zachrisson h, zetterberg f. lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the p2y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug azd1283. j med chem. 2013;56(17):7015-24. |
| | AZD1283 Preparation Products And Raw materials |
|