1-deoxysphingosine (M18:1) manufacturers
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| | 1-deoxysphingosine (M18:1) Basic information |
| Product Name: | 1-deoxysphingosine (M18:1) | | Synonyms: | 1-deoxysphingosine (M18:1);1-deoxysphingosine;1-DEOXYSPHINGOSINE (M18:1);1-DEOXYSPHINGOSINE;1-Deoxysphingosine (m18:1(4E));4-Octadecen-3-ol, 2-amino-, (2S,3R,4E)- | | CAS: | 193222-34-3 | | MF: | C18H37NO | | MW: | 283.49 | | EINECS: | | | Product Categories: | | | Mol File: | 193222-34-3.mol |  |
| | 1-deoxysphingosine (M18:1) Chemical Properties |
| Boiling point | 404.3±33.0 °C(Predicted) | | density | 0.882±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 2 mg/ml; Ethanol: miscible | | form | A crystalline solid | | pka | 12.14±0.45(Predicted) | | InChIKey | ZREXGWPJFRJAJU-SWESGNQDSA-N | | SMILES | C[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 1-deoxysphingosine (M18:1) Usage And Synthesis |
| Description | 1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 Plasma levels of 1-deoxysphingosine (m18:1(4E)) are increased in patients with chronic idiopathic axonal neuropathy (CIAP) and diabetic distal symmetrical polyneuropathy (DSPN).3 | | Uses | 1-Deoxysphingosine is elevated in lymphoblasts of individuals with hereditary sensory neuropathy type 1 (HSAN1) disorder; it features a (4E) double bond in its structure and is produced through the catabolism of 1-deoxyceramide catalyzed by the ceramidase enzyme, classifying it as an unsaturated deoxy-sphingoid base. | | References | 1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine J. Lipid Res. 57(7),1194-1203(2016).
2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway J. Lipid Res. 58(1),60-71(2017).
3. Hube, L., Dohrn, M.F., Karsai, G., et al. Metabolic syndrome, neurotoxic 1-deoxysphingolipids and nervous tissue inflammation in chronic idiopathic axonal polyneuropathy (CIAP) PLoS One 12(1):e0170583,(2017). |
| | 1-deoxysphingosine (M18:1) Preparation Products And Raw materials |
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