- 4-Hydroxynonenal
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- $48.00
-
2026-07-16
- CAS:75899-68-2
- Purity: 99.50%
- Supply Ability: 10g
- 4-Hydroxynonenal
-
- $48.00
-
2026-07-15
- CAS:75899-68-2
- Purity: 99.50%
- Supply Ability: 10g
- 4-Hydroxynonenal
-
- $48.00
-
2025-05-02
- CAS:75899-68-2
- Purity: 95.12%
- Supply Ability: 10g
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| Product Name: | HNE | | Synonyms: | Ccris 1781;(E)-4-HYDROXYNONENAL;HNE;(+/-)-4-HYDROXY-2E-NONENAL;(+/-)-4-HYDROXYNON-2-ENAL;4-hydroxy-2-nonena;(E)-4-hydroxynon-2-enal;2-Nonenal, 4-hydroxy-, (2E)- | | CAS: | 75899-68-2 | | MF: | C9H16O2 | | MW: | 156.22 | | EINECS: | | | Product Categories: | | | Mol File: | 75899-68-2.mol |  |
| Boiling point | 125-127 °C(Press: 2 Torr) | | density | 0.941±0.06 g/cm3(Predicted) | | storage temp. | -70°C | | solubility | DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml | | pka | 13.31±0.20(Predicted) | | form | Colorless oil. | | color | Colorless to light yellow | | InChI | InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+ | | InChIKey | JVJFIQYAHPMBBX-FNORWQNLSA-N | | SMILES | C(=O)/C=C/C(O)CCCCC | | CAS DataBase Reference | 75899-68-2(CAS DataBase Reference) |
| WGK Germany | WGK 3 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 2 |
| Uses | HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 μM.[Cayman Chemical] | | Uses | 4-Hydroxynonenal is an irreversible inhibitor of Na+/K+-ATPase activity. | | Definition | ChEBI: 4-hydroxynon-2-enal is an enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position. It has a role as a human metabolite. It is a hydroxyaldehyde, an enal and a 4-hydroxynonenal. | | Biological Activity | Primary Target
Na+, K+-ATPase activity', 'Product does not compete with ATP.', 'Target IC50: 120 μM against Na+, K+-ATPase activity | | in vivo | Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2+/+) and Nrf2-deficient mice (Nrf2-/-) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2+/+ and Nrf2-/- mice. Similar to iNOS result, in Nrf2-/- KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2+/+ WT animals[2]. | | IC 50 | ALDH2; Human Endogenous Metabolite |
| | HNE Preparation Products And Raw materials |
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