MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE

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MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE Basic information
Product Name:MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE
Synonyms:ELASTASE INHIBITOR II;HNE INHIBITOR;MSACK;methoxysuccinyl-alanyl-alanyl-prolyl-alaninechloromethylketone;MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE;MEOSUC-ALA-ALA-PRO-ALA-CMK;methoxysuccinyl-Ala-Ala-Pro-Ala chloromethyl ketone;L-Prolinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-[(1S)-3-chloro-1-methyl-2-oxopropyl]-
CAS:111682-13-4
MF:C20H31ClN4O7
MW:474.94
EINECS:
Product Categories:ProteaseInhibitors
Mol File:111682-13-4.mol
MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE Structure
MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE Chemical Properties
Boiling point 810.8±65.0 °C(Predicted)
density 1.269±0.06 g/cm3(Predicted)
storage temp. -15°C
solubility Soluble in methanol or DMSO
pka13.13±0.20(Predicted)
form lyophilized solid
color white
Sensitive Moisture Sensitive
Safety Information
WGK Germany WGK 1
Storage Class11 - Combustible Solids
MSDS Information
MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE Usage And Synthesis
UsesA potent inhibitor of human neutrophil elastase (HNE).The inhibition results from cross-linking of catalytic residues His57 and Ser195 in the HNE in the presence of this inhibitor.
A potent irreversible inhibitor of human neutrophil elastase (HNE). Inhibition results from cross-linking of the catalytic residues His57 and Ser195.
DefinitionChEBI: A tripeptide derived from methoxysuccinyl-Ala-Ala-Pro-Ala by conversion of the terminal carboxy group to the corresponding chloromethyl ketone.
Biological ActivityPrimary Target
Human neutrophil elastase (HNE)
MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE Preparation Products And Raw materials
Tag:MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE(111682-13-4) Related Product Information
Elastase (human leucocytes) HNE MEOSUC-ALA-ALA-PRO-TRP-CMK MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE MEOSUC-LEU-ALA-PRO-PHE-CMK MEOSUC-TRP-ALA-PRO-LEU-CMK MEOSUC-ALA-ALA-PRO-ALA-CHLOROMETHYLKETONE