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| | Anti-PORC-PI-1 Basic information |
| Product Name: | Anti-PORC-PI-1 | | Synonyms: | ANTI-CDC45 antibody produced in rabbit;Anti-CDC45L antibody produced in rabbit;Anti-Cdc45;Anti-CDC45-related protein;Anti-CDC45L;Anti-PORC-PI-1;Anti-CDC45L2;Anti-CDC45 cell division cycle 45-like (S. cerevisiae) | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Anti-PORC-PI-1 Structure]() |
| | Anti-PORC-PI-1 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | rabbit |
| WGK Germany | WGK 1 | | Storage Class | 12 - Non Combustible Liquids |
| | Anti-PORC-PI-1 Usage And Synthesis |
| Uses | Anti-Cdc45, , is a highly specific rabbit polyclonal antibody that targets DNA replication protein Cdc45 and has been tested for use in Western Blotting.
Western Blotting Analysis: A 1:500 dilution from a representative lot detected Cdc45 in 10 µg of HeLa cell lysate.
Western Blotting Analysis: A representative lot detected Cdc45 in asynchronous, go synchronized and G1 released CHO cells, immunoprecipitated CDC45 from CHO cells, HeLa and NIH3T3 .
| | Biological Activity | CDC45 (cell division cycle 45) is an essential protein in the initiation of chromosomal DNA replication. It is a component of the multiprotein complex consisting of Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase. It interacts with MCM7 and DNA polymerase α and assists in the loading of DNA polymerase α onto chromatin. It is ubiquitylated and degraded during apoptosis. Deletion of CD45 gene causes DiGeorge syndrome with parathyroid hypoplasia, thymic aplasia, or hypoplasia and congenital cardiac abnormalities. |
| | Anti-PORC-PI-1 Preparation Products And Raw materials |
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