- DIFETHIALONE
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2026-06-30
- CAS:104653-34-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kgs
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| | DIFETHIALONE Basic information |
| Product Name: | DIFETHIALONE | | Synonyms: | LM2219;DIFETHIALONE;GENERATION;2H-1-Benzothiopyran-2-one, 3-3-(4-bromo1,1-biphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl-4-hydroxy-;2H-1-Benzothiapyran-2-one, 3-(3-(4'-bromo(1,1'-biphenyl)-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl)-4-hydroxy-;RODILON;2h-1-benzothiopyran-2-one,3-(3-(4’-bromo(1,1’-biphenyl)-4-yl)-1,2,3,4-tetrahyd;ro-1-naphthalenyl)-4-hydroxy- | | CAS: | 104653-34-1 | | MF: | C31H23BrO2S | | MW: | 539.48 | | EINECS: | | | Product Categories: | | | Mol File: | 104653-34-1.mol |  |
| | DIFETHIALONE Chemical Properties |
| Melting point | 203-227° | | Boiling point | 658.3±55.0 °C(Predicted) | | density | 1.3614 g/cm3(Temp: 25 °C) | | solubility | Chloroform: slightly soluble; Methanol: slightly soluble | | form | A solid | | pka | 4.50±1.00(Predicted) | | Henry's Law Constant | 9.9×100 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) | | EPA Substance Registry System | Difethialone (104653-34-1) |
| RIDADR | UN2588 (Pesticide, solid, poi-
sonous, n.o.s.); UN2902 (Pesticide, liquid, poisonous,
n.o.s.) | | HS Code | 29349990 | | Hazardous Substances Data | 104653-34-1(Hazardous Substances Data) | | Toxicity | LD50 orally in male, female rats, mice (mg/kg): 0.62, 0.42, 0.52, 0.43 (non-resistant); 0.27, 0.39, 0.46, 0.52 (warfarin resistant); LD50 in hare: 0.75 mg/kg; LC50 in mallard duck, bobwhite quail (ppm): 1.94, 0.56; LD50 at 48 hrs in daphnia magna, bluegill sunfish, rainbow trout (mg/l): 4.4, 110, 67 (Lechevin) |
| | DIFETHIALONE Usage And Synthesis |
| Description | Difethialone[104653-34-1], 3-[(1RS,3RS; 1RS,3SR)-3-
(4 -bromobiphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]-
4-hydroxy-1-benzothiin-2-one, C31H23BrO2S, MW 539.5,
mp 233–236 C, is a slightly yellowish powder which
is practically insoluble in water, moderately soluble in
ethanol, methanol, hexane, acetone, readily soluble in chloroform,
dimethylformamide [9, p. 393]. | | Uses | Difethialone is an anticoagulant rodenticide widely used to control rodent infestations. | | Uses | Pesticide. | | Preparation | Difethialone is made by condensation of 4-hydroxy-2H-
1-benzothiapyran-2-one with 3-(4 -bromo-4-biphenyl)-1,2,
3,4-tetrahydro-1-naphthol in acetic acid containing concentrated
sulfuric acid (62). | | Definition | ChEBI: Difethialone is a member of benzenes, a member of naphthalenes and a ring assembly. | | Agricultural Uses | Rodenticide, Pesticide: Introduced in 1986, this second-generation anticoagulant rodenticide (member of the hydroxy-4-benzothiopyranone family) is used to control mice and rats, including
those resistant to first-generation anticoagulants. Not approved for use in most EU countries. Approved for use
in the U.S. | | Trade name | LM-2219®; PROTECTA RAT BAIT
STATION®; VETERAN PELLET®; VETERAN WAX
BLOCK® | | Mechanism of action | Difethialone is an anticoagulant rodenticide that disrupts the normal blood clotting mechanisms in its target species. It works by inhibiting the enzyme Vitamin K epoxide reductase (VKORC1), which is crucial for the synthesis of blood clotting factors resulting in an increased bleeding tendency and eventually death. | | Pesticide Type | Rodenticide |
| | DIFETHIALONE Preparation Products And Raw materials |
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