- N3-PEG1-NHS
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2026-07-24
- CAS:1807530-06-8
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | Azido-PEG1-NHS ester Basic information |
| Product Name: | Azido-PEG1-NHS ester | | Synonyms: | AZIDO-PEG1-NHS;Azido-PEG1-NHS ester;N3-PEG1-CH2CH2COONHS;2,5-dioxopyrrolidin-1-yl 3-(2-azidoethoxy)propanoate;3-(2-Azidoethoxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester | | CAS: | 1807530-06-8 | | MF: | C9H12N4O5 | | MW: | 256.22 | | EINECS: | | | Product Categories: | | | Mol File: | 1807530-06-8.mol |  |
| | Azido-PEG1-NHS ester Chemical Properties |
| storage temp. | -20°C, sealed storage, away from moisture and light | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | Azido-PEG1-NHS ester Usage And Synthesis |
| Description | Azido-PEG1-NHS ester is a click chemistry PEG reagent with broad application. Azide(N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | | Uses | Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG1-NHS ester Preparation Products And Raw materials |
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