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| | Azido-PEG1-t-butyl ester Basic information |
| Product Name: | Azido-PEG1-t-butyl ester | | Synonyms: | Azido-PEG1-t-butyl ester;tert-Butyl 3-(2-azidoethoxy)propanoate;CAS_1374658-85-1;Azido-PEG1-Boc;Azido-PEG1-t-butyl ester,N3-PEG1-t-butyl ester,Azido-PEG1-Boc;Azido-PEG1-tBu Ester | | CAS: | 1374658-85-1 | | MF: | C9H17N3O3 | | MW: | 215.24958 | | EINECS: | | | Product Categories: | | | Mol File: | 1374658-85-1.mol |  |
| | Azido-PEG1-t-butyl ester Chemical Properties |
| storage temp. | Store at 0-8 °C | | form | Oil | | color | Colorless to light yellow |
| | Azido-PEG1-t-butyl ester Usage And Synthesis |
| Description | Azido-PEG1-t-butyl ester is a azide containing molecules. it can react with alkyne, such as BCN, DBCO via Click Chemistry to yield a stable triazole linkage. | | Uses | Azido-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG1-t-butyl ester Preparation Products And Raw materials |
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