- GSK-F1
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- $112.00
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2026-05-11
- CAS:1402345-92-9
- Purity: 97.03%
- Supply Ability: 10g
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| Product Name: | GSK-F1 | | Synonyms: | GSK-F1;rac-GSK-F1;CS-2666;PI4KA inhibitor-F1;3-Pyridinesulfonamide, 5-[2-amino-3,4-dihydro-4-oxo-3-[2-(trifluoromethyl)phenyl]-6-quinazolinyl]-N-(2,4-difluorophenyl)-2-methoxy-;5-{2-Amino-4-oxo-3-[2-(trifluoromethyl)phenyl]-3,4-dihydro-6-quinazolinyl}-N-(2,4-difluorophenyl)-2-methoxy-3-pyridinesulfonamide;hepatitis C virus,Phosphoinositide 3-kinase,Inhibitor,HEK293-AT1 cells,GSK-F-1,PI4K,Phosphatidylinositol 4 kinases,GSK-F1,HCV,GSKF1,COS-7,inhibit,GSK F1,PI4 kinases,PI3K;GSK-F1, 10 mM in DMSO | | CAS: | 1402345-92-9 | | MF: | C27H18F5N5O4S | | MW: | 603.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1402345-92-9.mol |  |
| | GSK-F1 Chemical Properties |
| Boiling point | 744.3±70.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, sealed storage, away from moisture and light | | solubility | DMSO : 125 mg/mL (207.12 mM; Need ultrasonic) | | form | Solid | | pka | 5.66±0.50(Predicted) | | color | White to off-white |
| | GSK-F1 Usage And Synthesis |
| Uses | GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research[1]. | | IC 50 | PI4KA: 8.0 (pIC50); PI3KD: 6.4 (pIC50); PI4KB: 5.9 (pIC50); PI3KB: 5.9 (pIC50); PI3KG: 5.9 (pIC50); PI3KA: 5.8 (pIC50) | | References | [1] Bojjireddy N, et al. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem. 2014 Feb 28;289(9):6120-32. DOI:10.1074/jbc.M113.531426 |
| | GSK-F1 Preparation Products And Raw materials |
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