PF 4693627

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PF 4693627 manufacturers

  • PF-4693627
  • PF-4693627 pictures
  • $2160.00
  • 2026-05-11
  • CAS:1312815-93-2
  • Purity:
  • Supply Ability: 10g
PF 4693627 Basic information
Product Name:PF 4693627
Synonyms:PF 4693627;PF 4693627 - PF 04693627;PF 4693627,PF4693627;4-Piperidinecarboxamide, 1-[5-chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-
CAS:1312815-93-2
MF:C26H29Cl2N3O3
MW:502.433
EINECS:
Product Categories:
Mol File:1312815-93-2.mol
PF 4693627 Structure
PF 4693627 Chemical Properties
density 1.38±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 5 mg/ml
form A crystalline solid
pka15.05±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
PF 4693627 Usage And Synthesis
DescriptionPF-4693627 is a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
UsesPF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA)[1].
in vivo

PF-4693627 (10 mg/kg; orally) inhibits 63% of PGE2 production relative to vehicle control in Guinea pig carrageenan stimulated air pouch model[1].
PF-4693627 (1.0 mg/kg; i.v.) shows good bioavailability (59%) and modest half life (t1/2=3.7 h) in Sprague-Dawley rats[1].

Animal Model:Guinea pig with carrageenan stimulated air pouch inflammation model[1]
Dosage:10 mg/kg
Administration:Administered orally
Result:63% PGE2 inhibition.
Animal Model:Sprague-Dawley rats[1].
Dosage:1.0 mg/kg (Pharmacokinetic Analysis)
Administration:Administered i.v.
Result:Clearance (CL), volume of distribution (Vdss), t1/2, mean residence time (MRT) and bioavailability (F) is 12 mL/min/kg, 3.0 L/kg, 3.7 h, 4.42 h, 59%, respectively.
References[1] Arhancet GB, et al. Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1114-9. DOI:10.1016/j.bmcl.2012.11.109
PF 4693627 Preparation Products And Raw materials
Tag:PF 4693627(1312815-93-2) Related Product Information
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