| Company Name: |
BOC Sciences |
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1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
PF-9184 manufacturers
- PF-9184
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- $41.00
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2026-07-16
- CAS:1221971-47-6
- Purity: 97.64%
- Supply Ability: 10g
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| | PF-9184 Basic information |
| Product Name: | PF-9184 | | Synonyms: | PF-9184;N-[3',4'-Dichloro(1,1'-biphenyl)-yl]-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide;PF-03549184;2H-1,2-Benzothiazine-3-carboxamide, N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-, 1,1-dioxide;PF9184,PF 9184;N-(3',4'-dichloro-[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide | | CAS: | 1221971-47-6 | | MF: | C21H14Cl2N2O4S | | MW: | 461.32 | | EINECS: | | | Product Categories: | | | Mol File: | 1221971-47-6.mol |  |
| | PF-9184 Chemical Properties |
| Melting point | 285.5-289.3 °C | | density | 1.574±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | ≤15mg/ml in DMSO;20mg/ml in dimethyl formamide | | pka | 4.50±1.00(Predicted) | | form | powder | | color | white to beige | | InChI | 1S/C21H14Cl2N2O4S/c22-16-10-7-13(11-17(16)23)12-5-8-14(9-6-12)25-19(21(24)27)20(26)15-3-1-2-4-18(15)30(25,28)29/h1-11,26H,(H2,24,27) | | InChIKey | YGTUCAUHSJOJCQ-UHFFFAOYSA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | PF-9184 Usage And Synthesis |
| Description | Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product prostaglandin H2 (PGH2; ) into the biologically active PGE2 . Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1β, and TNF-α. PF-9184 is a potent inhibitor of mPGES-1 (IC50 = 16.5 nM for recombinant human enzyme). It displays at least 6,500-fold selectivity for mPGES-1 over COX-1 and COX-2. PF-9184 blocks the synthesis of PGE2 in LPS-treated human whole blood and in IL-1β-stimulated fibroblasts (IC50s = 0.4-5 μM). | | Uses | PF 9184 is amicrosomal prostaglandin Esynthase-1(mPGES-1) inhibitor. mPGES-1is an enzyme induced during the inflammatory response and it is an attractive target for developing anti-inflammatory drugs. | | in vitro | pf-9184 potently inhibited recombinant human mpges-1 with an ic50 value of 16.5 ± 3.8 nm. pf-9184 showed no effect on rhcox-1 and rhcox-2 with >6500-fold selectivity. in rationally designed cell systems, pf-9184 inhibited pge2 synthesis with ic50 in the range of 0.5–5 μm in serum-free cell and human whole blood cultures, while sparing the synthesis of 6-keto-pgf1α (pgf1α) and pgf2α[1]. pf-9184 showed no apparent cytotoxic effects up to 100 μm [1]. | | Enzyme inhibitor | This potent mPGES-1 inhibitor (FW = 461.32 g/mol; CAS 1221971-47-6; Solubility: 100 mM in DMSO), also named N-[3',4'-dichloro(1,1'- biphenyl)yl]-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide), targets human and rat microsomal prostaglandin E synthase 1, with respective IC50 values of 16.5 nM and 1.08 μM, exhibiting >6500x selectivity toward mPGES-1 versus COX1 and COX2. PF-9184 inhibits IL- 1β-induced PGE2 synthesis in vitro. In inflammation and clinically relevant biological systems, mPGES-1 expression, like COX-2 expression is induced in cell context- and time-dependent manner, a behavior that is fully consistent with the kinetics of PGE2 synthesis | | in vivo | PF-9184 (oral administration or even local delivery) has no effect on PGE2 synthesis in recombinant rats[1]. | | references | [1] mbalaviele g, pauley a m, shaffer a f, et al. distinction of microsomal prostaglandin e synthase-1 (mpges-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mpges-1 inhibitor[j]. biochemical pharmacology, 2010, 79(10): 1445-1454.
[2] engblom d, saha s, engstrm l, et al. microsomal prostaglandin e synthase-1 is the central switch during immune-induced pyresis[j]. nature neuroscience, 2003, 6(11): 1137-1138.
[3] jakobsson p j, thorén s, morgenstern r, et al. identification of human prostaglandin e synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target[j]. proceedings of the national academy of sciences, 1999, 96(13): 7220-7225. |
| | PF-9184 Preparation Products And Raw materials |
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