287194-41-6
| 中文名称 | 287194-41-6 |
|---|---|
| 中文同义词 | 2-羟基-N-[(1R,2R,6R)-2-羟基-5-氧代-7-氧杂双环[4.1.0]庚-3-烯-3-基]苯甲酰胺;(+)-DHMEQ;化合物 T13462;化合物 (+)-DHMEQ |
| 英文名称 | (+)-DHMEQ |
| 英文同义词 | 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide;(1R,2R,6R)-Dehydroxymethylepoxyquinomicin;(1R,2R,6R)-DHMEQ;Benzamide, 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-;6R)-Dehydroxymethylepoxyquinomicin;6R)-DHMEQ;(+) DHMEQ,(+)DHMEQ |
| CAS号 | 287194-41-6 |
| 分子式 | C13H11NO5 |
| 分子量 | 261.23 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 287194-41-6.mol |
| 结构式 |  |
287194-41-6 性质
| 熔点 | 184 °C |
|---|---|
| 沸点 | 617.2±55.0 °C(Predicted) |
| 密度 | 1.58±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥35mg/mL（133.98mM） |
| 酸度系数(pKa) | 8.43±0.30(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
(+)-DHMEQ 是一种抗氧化转录因子 Nrf2 的激活剂。(+)-DHMEQ 是 (-)-DHMEQ 的对映体。(+)-DHMEQ 抑制 NF-kB 的活性低于(-)-DHMEQ。
Nrf2
(+)-DHMEQ ((2R,3R,4R)-DHMEQ) activates Nrf2, which is a transcription factor that induces the expression of multiple antioxidant enzymes. (+)-DHMEQ activates Nrf2 in a promoter reporter assay. (+)-DHMEQ also increases the expression of target antioxidant proteins and cancelled reactive oxygen species (ROS)-induced cell death in a neuronal cell line. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2.