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| | ALPHA-CGRP (RAT) Basic information |
| Product Name: | ALPHA-CGRP (RAT) | | Synonyms: | ALPHA-CALCITONIN GENE RELATED PEPTIDE, RAT;ALPHA-CGRP (RAT);CALCITONIN GENE RELATED PEPTIDE RAT;H-SER-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2;H-SER-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2 (DISULFIDE BRIDGE: 2-7);CGRP (RAT);SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (DISULFIDE BRIDGE: 2-7);SER-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASP-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-GLU-ALA-PHE-NH2 | | CAS: | 83651-90-5 | | MF: | C162H262N50O52S2 | | MW: | 3806.24748 | | EINECS: | | | Product Categories: | Peptide | | Mol File: | 83651-90-5.mol |  |
| | ALPHA-CGRP (RAT) Chemical Properties |
| storage temp. | −20°C | | form | powder | | color | White to off-white | | Water Solubility | Soluble to 0.80 mg/ml in water | | Sequence | H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7) |
| | ALPHA-CGRP (RAT) Usage And Synthesis |
| Uses | α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies[1][2][3][4]. | | in vivo | α-CGRP (mouse, rat) (0.25, 0.5, 1 μg/kg/min, intravenous) dose-dependent decreases mean arterial blood pressure, while heart rate and systemic vascular conduction increased, while cardiac output remained unchanged[3].
α-CGRP (mouse, rat) plays an important role in the regulation of Kainic acid (KA) induced pyramid-cell death in hippocampal CA3 region[4].
| | storage | Store at -20°C | | References | [1] Whitby K, et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol. 2005 Jul;79(14):8698-706. DOI:10.1128/JVI.79.14.8698-8706.2005
[2] Xu H, et al. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9. DOI:10.1016/j.immuni.2019.09.004
[3] Arulmani U, et al. Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats. Basic Clin Pharmacol Toxicol. 2004 Jun;94(6):291-7. DOI:10.1111/j.1742-7843.2004.pto940606.x
[4] Park SH, et al. Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice. Peptides. 2013 Jun;44:158-62. DOI:10.1016/j.peptides.2013.04.001 |
| | ALPHA-CGRP (RAT) Preparation Products And Raw materials |
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