CALCITONIN, HUMAN manufacturers
- CALCITONIN, HUMAN
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- $1.00
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2019-08-08
- CAS:21215-62-3
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg,10kg,100kg
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| | CALCITONIN, HUMAN Basic information |
| Product Name: | CALCITONIN, HUMAN | | Synonyms: | calcitonin M;THYROCALCITONIN HUMAN;H-CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2;H-CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 (DISULFIDE BRIDGE: 1-7);CYST-GLY-ASN-LEU-SER-THR-CYST-MET-LEU-GLY-THR-TYR-THR-GLN-AS-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO NH2;CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2;CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 HUMAN;CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-NH2 (DISULFIDE BRIDGE: 1-7) | | CAS: | 21215-62-3 | | MF: | C151H226N40O45S3 | | MW: | 3417.86 | | EINECS: | 244-276-2 | | Product Categories: | Peptide;Calcitonin and CGRP receptor | | Mol File: | 21215-62-3.mol |  |
| | CALCITONIN, HUMAN Chemical Properties |
| Boiling point | 3061.8±65.0 °C(Predicted) | | density | 1.326±0.06 g/cm3(Predicted) | | RTECS | XP3560000 | | storage temp. | −20°C | | solubility | Soluble in DMSO | | form | powder | | color | White to off-white | | biological source | synthetic (organic) | | Water Solubility | Soluble to 2 mg/ml in water | | Merck | 13,1642 | | Sequence | Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 (Disulfide bridge:Cys1-Cys7) | | InChIKey | LDVRMNJZLWXJPL-JKQNMTHDSA-N |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | CALCITONIN, HUMAN Usage And Synthesis |
| Uses | Regulator (calcium). | | Uses | Decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. A carrier peptide that can be used to internalize fusion proteins | | Uses | Calcitonin human has been used to study its ability to stimulate cAMP production post transfection in mammalian cell by activating human CALCRL (calcitonin receptor like receptor gene)- receptor activity-modifying protein 1 (RAMP1) and CTR (calcitonin receptor). | | Brand name | Calcimar (Rhone-
Poulenc Rorer);. | | Biochem/physiol Actions | Calcitonin, also referred to as thyrocalcitonin, is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compared to serum. It acts as a first messenger and hence regulates the the production of cAMP as well as mammalian sperm function. It also facilitates the regulation of different isoforms of adenylyl cyclase. | | in vivo | Calcitonin (oral gavage; 2 mg/kg; once daily; 9 w) can inhibit cartilage degradation and prevent cartilage erosion[3]. | Animal Model: | Female Sprague-Dawley rats[3] | | Dosage: | 2 mg/kg | | Administration: | Oral gavage; 2 mg/kg; once daily; 9 weeks | | Result: | Suppressed ovariectomy-induced cartilage degradation (P<0.001) compared with the carrier control.
Prevented cartilage erosion compared with treatment with the carrier alone (P<0.01), and the extent of erosions was comparable with that in sham-operated animals. |
| | storage | Store at -20°C |
| | CALCITONIN, HUMAN Preparation Products And Raw materials |
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