| Company Name: |
Nextpeptide Inc |
| Tel: |
+86-0571-81612335 +8613336028439 |
| Email: |
sales@nextpeptide.com |
|
| | 1,1,1-Trifluoroethyl-PEG5-Propargyl Basic information |
| Product Name: | 1,1,1-Trifluoroethyl-PEG5-Propargyl | | Synonyms: | 1,1,1-Trifluoroethyl-PEG5-Propargyl;1,1,1-Trifluoroethyl-PEG4-propargyl;3,6,9,12,15-Pentaoxaoctadec-17-yne, 1,1,1-trifluoro- | | CAS: | 1817735-37-7 | | MF: | C13H21F3O5 | | MW: | 314.3 | | EINECS: | | | Product Categories: | | | Mol File: | 1817735-37-7.mol |  |
| | 1,1,1-Trifluoroethyl-PEG5-Propargyl Chemical Properties |
| Boiling point | 353.9±37.0 °C(Predicted) | | density | 1.142±0.06 g/cm3(Predicted) |
| | 1,1,1-Trifluoroethyl-PEG5-Propargyl Usage And Synthesis |
| Description | 1,1,1-Trifluoroethyl-PEG5-Propargyl forms triazole linkage with azides via copper catalyzed azide-alkyne Click Chemistry. The trifluoroethyl group is reactive towards primary amine groups in proteins, antibody and other molecules and surfaces. | | Uses | 1,1,1-Trifluoroethyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | 1,1,1-Trifluoroethyl-PEG5-Propargyl Preparation Products And Raw materials |
|