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| | 1,1,1-Trifluoroethyl-PEG3-Propargyl Basic information |
| | 1,1,1-Trifluoroethyl-PEG3-Propargyl Chemical Properties |
| Boiling point | 243.5±35.0 °C(Predicted) | | density | 1.152±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | color | Colorless to light yellow |
| | 1,1,1-Trifluoroethyl-PEG3-Propargyl Usage And Synthesis |
| Description | 1,1,1-Trifluoroethyl-PEG3-Propargyl is a heterobifunctional reagent with an alkyne group and a trifluoroethyl group. The alkyne group reacts with azide compounds or biomolecules in copper catalyzed Click Chemistry to form a stable triazole linkage. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibody and other molecules and surfaces. | | Uses | 1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | 1,1,1-Trifluoroethyl-PEG3-Propargyl Preparation Products And Raw materials |
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