Boc-Aminooxy-PEG2-Azide

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Boc-Aminooxy-PEG2-Azide manufacturers
Boc-Aminooxy-PEG2-Azide Basic information
Product Name:Boc-Aminooxy-PEG2-Azide
Synonyms:Boc-Aminooxy-PEG2-Azide;t-Boc-Aminooxy-PEG2-azide;t-Boc-Aminooxy-PEG2-azide boc;Boc-NH-O-PEG3-N3;tert-Butyl (2-(2-(2-azidoethoxy)ethoxy)ethoxy)carbamate
CAS:252378-68-0
MF:C11H22N4O5
MW:290.31618
EINECS:
Product Categories:
Mol File:252378-68-0.mol
Boc-Aminooxy-PEG2-Azide Structure
Boc-Aminooxy-PEG2-Azide Chemical Properties
storage temp. Storage temp. 2-8°C
form Viscous Liquid
color Colorless to light yellow
Safety Information
MSDS Information
Boc-Aminooxy-PEG2-Azide Usage And Synthesis
Descriptiont-Boc-Aminooxy-PEG2-azide is a click chemistry crosslinker molecule. The azide group enables PEGylation via Click Chemistry. The protected aminooxy can be deprotected under acidic conditions and then can react with an aldehyde or ketone group to form a stable oxime linkage.
Usest-Boc-Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. t-Boc-Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50PEGs; Alkyl/ether
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Boc-Aminooxy-PEG2-Azide Preparation Products And Raw materials
Tag:Boc-Aminooxy-PEG2-Azide(252378-68-0) Related Product Information
Boc-Aminooxy-PEG2-amine Boc-aminooxy-PEG2-Propargyl Boc-aminooxy-PEG1-Propargyl Aminooxy-PEG2-azide Boc-Aminooxy-PEG3-amine t-Boc-Aminoxy-PEG3-Azide