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| | Boc-aminooxy-PEG2-Propargyl Basic information |
| Product Name: | Boc-aminooxy-PEG2-Propargyl | | Synonyms: | Boc-aminooxy-PEG2-Propargyl;t-Boc-aminooxy-PEG2-propargyl;Boc-NH-PEG2-propargyl;tert-butyl N-[2-(2-prop-2-ynoxyethoxy)ethoxy]carbamate;3,6,9-Trioxa-2-azadodec-11-ynoic acid, 1,1-dimethylethyl ester | | CAS: | 1895922-74-3 | | MF: | C12H21NO5 | | MW: | 259.3 | | EINECS: | | | Product Categories: | | | Mol File: | 1895922-74-3.mol |  |
| | Boc-aminooxy-PEG2-Propargyl Chemical Properties |
| density | 1.072±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | color | Colorless to light yellow |
| | Boc-aminooxy-PEG2-Propargyl Usage And Synthesis |
| Description | t-Boc-aminooxy-PEG2-propargyl is a click chemistry crosslinker. The propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to yield a stable triazole linkage. t-Boc-aminooxy can be deprotected under mild acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Boc-aminooxy-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Boc-aminooxy-PEG2-Propargyl Preparation Products And Raw materials |
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