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| | (R)-N-(1-amino-5-(2-chloroacetamidino)-1-oxopentan-2-yl)benzamide hydrochloride Basic information |
| | (R)-N-(1-amino-5-(2-chloroacetamidino)-1-oxopentan-2-yl)benzamide hydrochloride Chemical Properties |
| form | Solid | | color | White to light yellow |
| | (R)-N-(1-amino-5-(2-chloroacetamidino)-1-oxopentan-2-yl)benzamide hydrochloride Usage And Synthesis |
| Uses | D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1]. | | in vivo | D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ～10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1].
| | References | [1] Bicker KL, et al. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085. DOI:10.1021/ml300288d |
| | (R)-N-(1-amino-5-(2-chloroacetamidino)-1-oxopentan-2-yl)benzamide hydrochloride Preparation Products And Raw materials |
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