PAD4-IN-3

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PAD4-IN-3 Basic information
Product Name:PAD4-IN-3
Synonyms:PAD4-IN-3;Boronic acid, B-[3-[[[(1S)-4-[(2-chloro-1-iminoethyl)amino]-1-[[(phenylmethyl)amino]carbonyl]butyl]amino]carbonyl]phenyl]-
CAS:2642327-44-2
MF:C21H26BClN4O4
MW:444.72
EINECS:
Product Categories:
Mol File:2642327-44-2.mol
PAD4-IN-3 Structure
PAD4-IN-3 Chemical Properties
density 1.279±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka7.796±0.10(predicted)
Safety Information
MSDS Information
PAD4-IN-3 Usage And Synthesis
UsesPAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment[1].
References[1] Jia Y et al. Chitosan nanomedicine containing RGD peptide and PAD4 inhibitor based on phenyl boronate coupling inhibition of primary tumor growth and lung metastasis. Biomed Pharmacother. 2023 Dec;168:115826. DOI:10.1016/j.biopha.2023.115826
PAD4-IN-3 Preparation Products And Raw materials
Tag:PAD4-IN-3(2642327-44-2) Related Product Information
(R)-N-(1-amino-5-(2-chloroacetamidino)-1-oxopentan-2-yl)benzamide hydrochloride PAD4-IN-3 N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride D-Cl-amidine N-[(1S)-1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide hydrochloride Cl-Amidine