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| | S-Methyl methanethiolsulfonate Basic information |
| | S-Methyl methanethiolsulfonate Chemical Properties |
| Melting point | 117.0-119.0 °C | | Boiling point | 69-71 °C0.4 mm Hg(lit.) | | density | 1.337 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.513(lit.) | | Fp | 190 °F | | storage temp. | 2-8°C | | solubility | chloroform: soluble750mg + 5 ml Chloroformmg/mL, colorless to light greenish-yellow | | form | clear liquid | | color | Colorless to Red to Green | | Odor | at 0.10 % in propylene glycol. sulfurous pungent roasted | | Odor Type | sulfurous | | BRN | 1446059 | | Stability: | Water Sensitive | | Major Application | cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care | | InChI | 1S/C2H6O2S2/c1-5-6(2,3)4/h1-2H3 | | InChIKey | XYONNSVDNIRXKZ-UHFFFAOYSA-N | | SMILES | CSS(C)(=O)=O | | LogP | 0.247 (est) | | CAS DataBase Reference | 2949-92-0(CAS DataBase Reference) | | NIST Chemistry Reference | S-methyl methanethiosulphonate(2949-92-0) | | EPA Substance Registry System | Methanesulfonothioic acid, S-methyl ester (2949-92-0) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36-36/37/38-20/21/22 | | Safety Statements | 26-36/37/39 | | RIDADR | 3334 | | WGK Germany | 2 | | RTECS | PB2765000 | | F | 13 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | PackingGroup | III | | HS Code | 29309090 | | Storage Class | 10 - Combustible liquids | | Toxicity | mouse,LD50,intraperitoneal,9110ug/kg (9.11mg/kg),Toxicology and Applied Pharmacology. Vol. 72, Pg. 513, 1984. |
| | S-Methyl methanethiolsulfonate Usage And Synthesis |
| Chemical Properties | Light Yellow Liquid | | Uses | S-Methyl methanethiolsulfonate is used for the rapid and selective modification of sulfhydryl groups of enzymes and it is also useful for mapping the pore-lining regions of the ryanodine receptor. | | Uses | carbonyl reactive homobifunctional cross-linking reagent cleavable with periodate | | Uses | S-Methyl methanethiosulfonate was used as sulfenylating agent for β-keto sulfoxides, methylene compounds, half-esters of malonic acids and aryl Grignard reagents. It was also used as a reagent to trap the natural thiol-disulfide state of the proteins. | | Definition | ChEBI: A sulfonic acid derivative obtained by condensaton of methanesulfonic acid with methanethiol. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 49, p. 2281, 1984 DOI: 10.1021/jo00186a039
Synthetic Communications, 20, p. 365, 1990 DOI: 10.1080/00397919008052777 | | General Description | Interaction of S-methyl methanethiosulfonate (MMTS) with dipalmitoylphosphatidylcholine (DPPC) bilayers has been investigated by FTIR and surface-enhanced Raman spectroscopy. | | Purification Methods | Purify it by fractional distillation under reduced pressure, IR: 1350, 750 cm-1 . [Applegate et al. J Org Chem 38 943 1973, Beilstein 4 IV 31.] |
| | S-Methyl methanethiolsulfonate Preparation Products And Raw materials |
| Raw materials | 4-Cyclopentene-1,3-dione, 2,2,4-trichloro-5-hydroxy--->4-Cyclopentene-1,3-dione,2,2,4,5-tetrachloro--->1H-Inden-1-one,2,3,4,5,6,7-hexachloro--->2,3,4,4,5-pentachlorocyclopent-2-en-1-one-->Hexachloro-2-cyclopenten-1-one-->2,2,4,5,6,7-Hexachloro-1H-indene-1,3(2H)-dione-->Bis(methylthio)methane-->Dimethyl sulfide | | Preparation Products | Dichloromaleic anhydride-->Chloromethyl methyl sulfide-->NSC 54274 |
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