- Formononetin
-
-
2026-10-21
- CAS:485-72-3
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 1000kg
- Formononetin
-
-
2026-10-21
- CAS:485-72-3
- Min. Order: 10MG
- Purity: 98% HPLC
- Supply Ability: 100KG
- Formononetin
-
- $45.00
-
2026-08-04
- CAS:485-72-3
- Purity: 99.63%
- Supply Ability: 10g
|
| | Formononetin Basic information |
| | Formononetin Chemical Properties |
| Melting point | 256-260 °C | | Boiling point | 331.43°C (rough estimate) | | density | 1.1529 (rough estimate) | | vapor pressure | 0Pa at 25℃ | | refractive index | 1.4350 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 100 mg/ml). | | form | Powder | | pka | 6.99±0.20(Predicted) | | color | White to light beige | | λmax | 300nm(EtOH)(lit.) | | Merck | 14,4244 | | BRN | 237979 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. | | Major Application | food and beverages | | Cosmetics Ingredients Functions | SKIN PROTECTING
ANTIOXIDANT
SKIN CONDITIONING - MISCELLANEOUS | | InChI | 1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3 | | InChIKey | HKQYGTCOTHHOMP-UHFFFAOYSA-N | | SMILES | COc1ccc(cc1)C2=COc3cc(O)ccc3C2=O | | LogP | 1.7 at 25℃ | | CAS DataBase Reference | 485-72-3(CAS DataBase Reference) | | EPA Substance Registry System | 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26-36 | | WGK Germany | 3 | | RTECS | DJ3100114 | | HS Code | 29329990 | | Storage Class | 11 - Combustible Solids |
| | Formononetin Usage And Synthesis |
| Description | Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2Accelerates wound repair by increasing expression of Egr-1 transcription factor.3Potential cancer chemopreventive and chemotherapeutic.4Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5 | | Chemical Properties | off-white powder | | Uses | An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen. | | Uses | Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen. | | Uses | Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity. | | Definition | ChEBI: Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'. It has a role as a phytoestrogen and a plant metabolite. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-). | | General Description | Formononetin belongs to the isoflavones class of polyphenols. | | Flammability and Explosibility | Not classified | | Biochem/physiol Actions | Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa. | | References | [1] TAO NIE. The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity[J]. British Journal of Pharmacology, 2018, 175 9: 1439-1450. DOI:10.1111/bph.14139
[2] JYOTI GAUTAM. Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss.[J]. British Journal of Nutrition, 2017, 117 5: 645-661. DOI:10.1017/s0007114517000149
[3] JEONG-EUN HUH . Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways[J]. International immunopharmacology, 2011, 11 1: Pages 46-54. DOI:10.1016/j.intimp.2010.10.003
[4] SAMANTHA KAH LING ONG. Focus on Formononetin: Anticancer Potential and Molecular Targets.[J]. Cancers, 2019. DOI:10.3390/cancers11050611
[5] ZHENGZHAO LI . Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons[J]. Biomedicine & Pharmacotherapy, 2018, 106: Pages 349-354. DOI:10.1016/j.biopha.2018.06.041 |
| | Formononetin Preparation Products And Raw materials |
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