| Company Name: |
Energy Chemical |
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
|
| | RWTWIZDKEIWLKQ-AXBPLXCXSA-N Basic information |
| | RWTWIZDKEIWLKQ-AXBPLXCXSA-N Chemical Properties |
| solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White |
| | RWTWIZDKEIWLKQ-AXBPLXCXSA-N Usage And Synthesis |
| Description | Dextrorphan-d3 (tartrate) (Item No. 15810) is intended for use as an internal standard for the quantification of dextrorphan (tartrate) by GC- or LC-MS. Dextrorphan is categorized as an arylcyclohexylamine and is a metabolite of dextromethorphan (hydrobromide hydrate) , an antitussive found in cough medicines. Dextrorphan, while also having antitussive activity, is psychoactive, leading to the abuse of cough medicines containing the parent compound. Dextrorphan antagonizes NMDA and μ-opioid receptors (Kis = 54 and 420 nM, respectively) and inhibits norepinephrine and serotonin transporters (Kis = 340 and 401 nM, respectively). This product is intended for research and forensic applications. | | Uses | A labelled Dextrorphan. Orally active synthetic morphine analog. Analgesic (narcotic). The labelled d-form of Levorphanol. | | References | [1] YU-WEN CHEN. Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats.[J]. Anesthesia and analgesia, 2007, 104 5: 1251-1255, tables of contents. DOI: 10.1213/01.ane.0000260330.18745.a8
[2] EUN-JOO SHIN . Neuropsychotoxicity of Abused Drugs: Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects[J]. Journal of pharmacological sciences, 2008, 106 1: Pages 22-27. DOI: 10.1254/jphs.fm0070177
[3] M DEMATTEIS M M G Lallement. Dextromethorphan and dextrorphan in rats: Common antitussives — Different behavioural profiles[J]. Fundamental & Clinical Pharmacology, 2009, 12 5: 526-537. DOI: 10.1111/j.1472-8206.1998.tb00982.x
[4] YUEH-CHING CHOU . Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan[J]. Brain Research, 1999, 821 2: Pages 516-519. DOI: 10.1016/s0006-8993(99)01125-7
[5] K L NICHOLSON R L B B A Hayes. Evaluation of the reinforcing properties and phencyclidine-like discriminative stimulus effects of dextromethorphan and dextrorphan in rats and rhesus monkeys.[J]. Psychopharmacology, 1999, 146 1: 49-59. DOI: 10.1007/s002130051087 |
| | RWTWIZDKEIWLKQ-AXBPLXCXSA-N Preparation Products And Raw materials |
|