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| | BAM-22P Basic information |
| Product Name: | BAM-22P | | Synonyms: | TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-TRP-TRP-MET-ASP-TYR-GLN-LYS-ARG-TYR-GLY;YGGFMRRVGRPEWWMDYQKRYG;BAM22;L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Arg-L-Val-Gly-L-Arg-L-Pro-L-Glu-L-Trp-L-Trp-L-Met-L-Asp-L-Tyr-L-Gln-L-Lys-L-Arg-L-Tyr-Gly-OH;Peptide E(1-22);ADTB1;AP105A;AP1B1 | | CAS: | 76622-26-9 | | MF: | C130H184N38O31S2 | | MW: | 2839.23 | | EINECS: | | | Product Categories: | Peptide;Various Peptides | | Mol File: | 76622-26-9.mol |  |
| | BAM-22P Chemical Properties |
| density | 1.50±0.1 g/cm3(Predicted) | | RTECS | SC6200500 | | storage temp. | -15°C | | solubility | Soluble to 1 mg/ml in H2O | | form | Lyophilized solid | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly |
| | BAM-22P Usage And Synthesis |
| Uses | BAM-22P, a highly potent opioid peptide, is a potent opioid agonist. | | Biological Activity | bovine adrenal medulla 22 peptide (bam22p) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin a, the precursor of leu- and met-enkephalin, in the adrenal medulla, with very potent opiate activity. | | in vitro | in the guinea-pig ileum assay, bam-22p has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. the potency of bam-22p is 26 times that of met-enkephalin and 22 times that of b hendorphin. ic50 value of bam-22p in this tissue, 1.3 nm, makes it the most potent met-enkephalin relatives that discoveried so far. [1]. | | in vivo | intrathecal (i.t.) administration of bam22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. such decrease was partially attenuated by systemic injection of naloxone. [2]. | | target | | | IC 50 | 1.3 nm for opiate activity | | references | [1] mizuno k, minamino n, kangawa k, matsuo h. a new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (bam-22p) and eicosapeptide (bam-20p) with very potent opiate activity. biochem biophys res commun. 1980 dec 31;97(4):1283-90.
[2] hong y, dai p, jiang j, zeng x. dual effects of intrathecal bam22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor. br j pharmacol. 2004 feb;141(3):423-30. |
| | BAM-22P Preparation Products And Raw materials |
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