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| | 2-HYDROXY-5-IODO-BENZONITRILE Basic information | | Application |
| | 2-HYDROXY-5-IODO-BENZONITRILE Chemical Properties |
| Melting point | 115-117℃ | | Boiling point | 321℃ | | density | 2.09 | | Fp | 148℃ | | storage temp. | 2-8°C, protect from light, stored under nitrogen | | pka | 6.55±0.18(Predicted) | | Appearance | White to light yellow Solid |
| | 2-HYDROXY-5-IODO-BENZONITRILE Usage And Synthesis |
| Application | 2-Hydroxy-5-iodobenzonitrile is an organic intermediate that can be used to prepare tert-butyl 4-((2-(aminomethyl)-4-iodophenoxy)methyl)piperidine-1-carboxylate. 4-((2-(aminomethyl)-4-iodophenoxy)methyl)piperidine-1-carboxylate and related derivatives have wide applications in medicinal chemistry and organic synthesis. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x | | Synthesis | (1)Synthesis of 5-iodo-2-hydroxybenzaldehyde oxime Add 30g 5-iodo-2-hydroxybenzaldehyde to 270ml ethanol, dropwise add 17g hydroxylamine hydrochloride, room temperature stirring overnight, cooling, add water and ethyl acetate, extraction and partitioning, collection of the organic phase, drying, concentration, 23g 5-iodo-2-hydroxybenzaldehyde oxime was obtained. (2) Synthesis of 2-hydroxy-5-iodobenzonitrile Add 23g 5-iodo-2-hydroxybenzaldehyde oxime to 190ml acetic anhydride, heat and reflux stirring for 2 hours, concentrate, pour the residue into ice water, add ethyl acetate to extract the liquid, collect the organic phase, dry, concentrate, and get 16g 2-hydroxy-5-iodobenzonitrile separated by column. |
| | 2-HYDROXY-5-IODO-BENZONITRILE Preparation Products And Raw materials |
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