2-Hydroxy-5-iodo-benzonitrile

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2-Hydroxy-5-iodo-benzonitrile Basic information
Application
Product Name:2-Hydroxy-5-iodo-benzonitrile
Synonyms:2-HYDROXY-5-IODO-BENZONITRILE ISO 9001：2015 REACH;Benzonitrile, 2-hydroxy-5-iodo-;5-IODO-2-HYDROXYBENZONITRILE;2-Hydroxy-5-iodobenzonitril;2-Hydroxy-5-iodo-benzonitrile
CAS:685103-95-1
MF:C7H4INO
MW:245.02
EINECS:
Product Categories:Aromatic Nitriles;Iodine Compounds
Mol File:685103-95-1.mol
2-Hydroxy-5-iodo-benzonitrile Structure
2-Hydroxy-5-iodo-benzonitrile Chemical Properties
Melting point 115-117℃
Boiling point 321℃
density 2.09
Fp 148℃
storage temp. 2-8°C, protect from light, stored under nitrogen
pka6.55±0.18(Predicted)
AppearanceWhite to light yellow Solid
Safety Information
MSDS Information
2-Hydroxy-5-iodo-benzonitrile Usage And Synthesis
Application2-Hydroxy-5-iodobenzonitrile is an organic intermediate that can be used to prepare tert-butyl 4-((2-(aminomethyl)-4-iodophenoxy)methyl)piperidine-1-carboxylate. 4-((2-(aminomethyl)-4-iodophenoxy)methyl)piperidine-1-carboxylate and related derivatives have wide applications in medicinal chemistry and organic synthesis.
Synthesis Reference(s)The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x
Synthesis

(1)Synthesis of 5-iodo-2-hydroxybenzaldehyde oxime

Add 30g 5-iodo-2-hydroxybenzaldehyde to 270ml ethanol, dropwise add 17g hydroxylamine hydrochloride, room temperature stirring overnight, cooling, add water and ethyl acetate, extraction and partitioning, collection of the organic phase, drying, concentration, 23g 5-iodo-2-hydroxybenzaldehyde oxime was obtained.

(2) Synthesis of 2-hydroxy-5-iodobenzonitrile

Add 23g 5-iodo-2-hydroxybenzaldehyde oxime to 190ml acetic anhydride, heat and reflux stirring for 2 hours, concentrate, pour the residue into ice water, add ethyl acetate to extract the liquid, collect the organic phase, dry, concentrate, and get 16g 2-hydroxy-5-iodobenzonitrile separated by column.

2-Hydroxy-5-iodo-benzonitrile Preparation Products And Raw materials
Tag:2-Hydroxy-5-iodo-benzonitrile(685103-95-1) Related Product Information
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