| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Z-PHE-PHE-FLUOROMETHYLKETONE
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Shanghai Changyan Chem & Tech Co., Ltd.
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| Tel: |
021-20242659 18930833303 |
| Email: |
Sales@changyanchem.cn |
| Products Intro: |
Product Name:Z-FF-FMK
CAS:108005-94-3
Purity:95% HPLC Package:5KG;1KG;500G;100G;50G
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| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
|
| Tel: |
0571-87213919 |
| Email: |
Eric@peptidego.com |
| Products Intro: |
Product Name:Z-Phe-Phe-FMK
CAS:108005-94-3
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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Z-PHE-PHE-FLUOROMETHYLKETONE manufacturers
- (Rac)-Z-Phe-Phe-FMK
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- $199.00 / 1mg
-
2025-12-22
- CAS:108005-94-3
- Min. Order:
- Purity: 98.27%
- Supply Ability: 10g
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| | Z-PHE-PHE-FLUOROMETHYLKETONE Basic information |
| Product Name: | Z-PHE-PHE-FLUOROMETHYLKETONE | | Synonyms: | Z-PHE-PHE-FLUOROMETHYLKETONE;Z-PHE-PHE-FMK;Z-FF-FMK;Carbamic acid, [2-[[3-fluoro-2-oxo-1-(phenylmethyl)propyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester (9CI);Cathepsin L-IN-2;(Rac)-Z-Phe-Phe-FMK | | CAS: | 108005-94-3 | | MF: | C27H27FN2O4 | | MW: | 462.51 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | Z-PHE-PHE-FLUOROMETHYLKETONE Chemical Properties |
| Boiling point | 707.5±60.0 °C(Predicted) | | density | 1.214±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: 20mM | | form | solid | | pka | 11.07±0.46(Predicted) | | color | White to off-white | | InChI | 1S/C27H27FN2O4/c28-18-25(31)23(16-20-10-4-1-5-11-20)29-26(32)24(17-21-12-6-2-7-13-21)30-27(33)34-19-22-14-8-3-9-15-22/h1-15,23-24H,16-19H2,(H,29,32)(H,30,33) | | InChIKey | CAILNONEKASNSH-UHFFFAOYSA-N | | SMILES | FCC(=O)C(NC(=O)C(NC(=O)OCc3ccccc3)Cc2ccccc2)Cc1ccccc1 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | Z-PHE-PHE-FLUOROMETHYLKETONE Usage And Synthesis |
| Uses | Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L/B inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis. | | Biological Activity | Cell permeable: yes', 'Primary Target
cathepsin L', 'Product does not compete with ATP.', 'Reversible: no | | IC 50 | Cathepsin B; cathepsin L | | References | [1] Jonathan Frew, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 Mar 16;15(1):21. DOI:10.1186/s13024-020-00369-5 |
| | Z-PHE-PHE-FLUOROMETHYLKETONE Preparation Products And Raw materials |
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