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| | 9-Keto fluprostenol Basic information |
| Product Name: | 9-Keto fluprostenol | | Synonyms: | FLUPROSTENOL PROSTAGLANDIN E2;9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR PROSTA-5Z,13E-DIEN-1-OIC ACID;Travoprost Impurity 15（9-keto Fluprostenol）;5-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-5-oxocyclopentyl]-, (5Z)-;Travoprost Impurity 34;5-Heptenoic acid,7-[3-hydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]-5-oxocyclopentyl]-,[1R-[1a(Z),2b(1E,3R*),3a]]- (9CI);9-ketofluprostol;9-Keto fluprostenol | | CAS: | 156406-33-6 | | MF: | C23H27F3O6 | | MW: | 456.45 | | EINECS: | | | Product Categories: | | | Mol File: | 156406-33-6.mol |  |
| | 9-Keto fluprostenol Chemical Properties |
| Boiling point | 607.6±55.0 °C(Predicted) | | density | 1.331±0.06 g/cm3(Predicted) | | solubility | Ethanol: Miscible; PBS (7.2): 10 mg/ml | | pka | 4.75±0.10(Predicted) |
| | 9-Keto fluprostenol Usage And Synthesis |
| Description | 9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist. However, no studies on the pharmacology of this compound have been published to date. | | Uses | 9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist. However, no studies on the pharmacology of this compound have been published to date. | | Uses | 9-Keto Fluprostenol is an impurity of Fluprostenol (F500753), a FP prostaglandin receptor. | | References | [1] M. DUKES A. L W W RUSSELL. Potent luteolytic agents related to prostaglandin F2α[J]. Nature, 1974, 250 5464: 330-331. DOI: 10.1038/250330a0 |
| | 9-Keto fluprostenol Preparation Products And Raw materials |
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