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| | C18 L-threo Ceramide (d18:1/18:0) Basic information |
| Product Name: | C18 L-threo Ceramide (d18:1/18:0) | | Synonyms: | C18 L-threo Ceramide (d18:1/18:0);Octadecanoyl-L-threo-sphingosine;Octadecanamide, N-[(1S,2S,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-;N-[(1S,2S,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octadecanamide | | CAS: | 95037-06-2 | | MF: | C36H71NO3 | | MW: | 565.95 | | EINECS: | | | Product Categories: | | | Mol File: | 95037-06-2.mol |  |
| | C18 L-threo Ceramide (d18:1/18:0) Chemical Properties |
| Boiling point | 694.5±55.0 °C(Predicted) | | density | 0.915±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | A solid | | pka | 13.54±0.20(Predicted) |
| | C18 L-threo Ceramide (d18:1/18:0) Usage And Synthesis |
| Description | C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids.1 It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 8.8 μM.2 | | Uses | Octadecanoyl-L-threo-sphingosine is an ester product. | | References | 1. Sarmientos, F., Schwarzmann, G., and Sandhoff, K. Direct evidence by carbon-13 NMR spectroscopy for the erythro configuration of the sphingoid moiety in Gaucher cerebroside and other natural sphingolipids Eur. J. Biochem. 146(1),59-64(1985).
2. Usta, J., El Bawab, S., Roddy, P., et al. Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase Biochemistry 40(32),9657-9668(2001). |
| | C18 L-threo Ceramide (d18:1/18:0) Preparation Products And Raw materials |
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