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| | BI Compound D Basic information |
| Product Name: | BI Compound D | | Synonyms: | BI Compound D;4-Amino-8-[3-[(3,4-dimethoxyphenethyl)amino]propyl]-6,6-dimethyl-2-(4-methyl-3-nitrophenyl)-3H-imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione;3H-Imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione, 4-amino-8-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-6,6-dimethyl-2-(4-methyl-3-nitrophenyl)-;OUN58101;4-Amino-8-(3-(propyl)-6,6-dimethyl-2-(4-methyl-3-nitrophenyl)-3H-imida;RSV L-protein-IN-1 | | CAS: | 851658-10-1 | | MF: | C32H36N6O6 | | MW: | 600.66 | | EINECS: | | | Product Categories: | | | Mol File: | 851658-10-1.mol |  |
| | BI Compound D Chemical Properties |
| Boiling point | 853.4±75.0 °C(Predicted) | | density | 1.292±0.06 g/cm3(Predicted) | | pka | 9.93±0.19(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | BI Compound D Usage And Synthesis |
| Description | OUN58101, also known as MDK-8101, also known as BI-D, is a RSV L-protein inhibitor. OUN58101 was first reported in patnet WO 2005042530. This product has no formal name at the moment. | | Uses | RSV L-protein-IN-1 (compound D) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.021 μM). RSV L-protein-IN-1 inhibits Polymerase (IC50=0.089 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-1 shows moderate cytotoxicity (CC50=8.4 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection[1]. | | References | [1] Liuzzi M, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005 Oct;79(20):13105-15. DOI:10.1128/JVI.79.20.13105-13115.2005 |
| | BI Compound D Preparation Products And Raw materials |
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