RSV L-protein-IN-5 manufacturers
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| | RSV L-protein-IN-5 Basic information |
| Product Name: | RSV L-protein-IN-5 | | Synonyms: | RSV L-protein-IN-5;3H-Imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione, 4-amino-8-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-6,6-dimethyl-2-(6-methyl-2-pyridinyl)- | | CAS: | 851658-28-1 | | MF: | C31H36N6O4 | | MW: | 556.66 | | EINECS: | | | Product Categories: | | | Mol File: | 851658-28-1.mol |  |
| | RSV L-protein-IN-5 Chemical Properties |
| Boiling point | 825.016±75.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.248±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 8.543±0.40(predicted) |
| | RSV L-protein-IN-5 Usage And Synthesis |
| Uses | RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.1 μM). RSV L-protein-IN-5 inhibits Polymerase (IC50=0.66 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection[1]. | | References | [1] Liuzzi M, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005 Oct;79(20):13105-15. DOI:10.1128/JVI.79.20.13105-13115.2005 |
| | RSV L-protein-IN-5 Preparation Products And Raw materials |
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