CD38 inhibitor
| 中文名称 | CD38 inhibitor |
|---|---|
| 中文同义词 | 4-((反式-4-(2-甲氧基乙氧基)环己基)氨基)-1-甲基-6-(噻唑-5-基)喹啉-2(1H)-酮;化合物CD38 INHIBITOR 1;4-[[反式-4-(2-甲氧基乙氧基)环己基]氨基]-1-甲基-6-(5-噻唑基)喹啉-2(1H)-酮;PERFEMIKER]CD38 INHIBITOR 78C,98%;CD38 抑制剂;化合物CD38 INHIBITOR 1,10 MM DMSO 溶液;CD38 inhibitor 1 (compound 78c) CD38 inhibitor 1 (compound 78c),S8960 |
| 英文名称 | CD38 inhibitor 78c |
| 英文同义词 | 2(1H)-Quinolinone, 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-;4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone;4-((trans-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one;4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)quinolin-2(1H)-one;4- (trans 4- (2-methoxyethoxy) cyclohexyl) amino) -1-methyl-6- (thiazol-5-yl) quinoline-2 (1H) - one;Cluster of Differentiation 38 Inhibitor;Compound-78c;MDK 7553 |
| CAS号 | 1700637-55-3 |
| 分子式 | C22H27N3O3S |
| 分子量 | 413.53 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂 |
| Mol文件 | 1700637-55-3.mol |
| 结构式 |  |
CD38 inhibitor 性质
| 沸点 | 589.8±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：25 mg/mL（60.46 mM；超声加热并加热至 60°C） |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.17±0.20(Predicted) |
| 颜色 | 浅黄至棕色 |
| InChI | InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17- |
| InChIKey | VJQALSOBHVEJQM-QAQDUYKDSA-N |
| SMILES | N1(C)C2=C(C=C(C3SC=NC=3)C=C2)C(N[C@@H]2CC[C@@H](OCCOC)CC2)=CC1=O |
CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553)是一种有效的 CD38 抑制剂，对人CD38和小鼠CD38的IC50分别为7.3 nM和1.9 nM。
| Target | Value |
|
mCD38
(Cell-free assay) | 1.9 nM |
|
hCD38
(Cell-free assay) | 7.3 nM |
CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle.
| Animal Model: | Diet induced obese (DIO) C57Bl6 mice |
| Dosage: | 30 mg/kg |
| Administration: | Orally once |
| Result: | NAD levels were significantly increased at both the 2 and 6 h time points in liver and muscle. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-123999 | CD38 inhibitor CD38 inhibitor 1 | 1700637-55-3 | 1mg | 600元 |
| 2025/12/22 | HY-123999 | CD38 inhibitor CD38 inhibitor 1 | 1700637-55-3 | 10mM * 1mLin DMSO | 1370元 |