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| | tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate Basic information |
| Product Name: | tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate | | Synonyms: | tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate;CBM 301940;Butanoic acid, 3-[[[4,5-dihydro-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-3-isoxazolyl]carbonyl]amino]-, 1,1-dimethylethyl ester | | CAS: | 902146-11-6 | | MF: | C15H20F6N2O5 | | MW: | 422.32 | | EINECS: | | | Product Categories: | | | Mol File: | 902146-11-6.mol |  |
| | tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate Chemical Properties |
| density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.06±0.29(Predicted) | | form | Solid | | color | White to off-white |
| | tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate Usage And Synthesis |
| Uses | CBM-301940 (compound 5) is an orally active malonate CoA decarboxylase (MCD) inhibitor with IC50 value of 23 nM. CBM-301940 can be used in the study of cardiovascular diseases[1]. | | storage | Store at -20°C | | References | [1] Cheng JF, et al. Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J Med Chem. 2006 Jul 13;49(14):4055-8. doi: 10.1021/jm0605029. PMID: 16821767. DOI:10.1021/jm0605029 |
| | tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate Preparation Products And Raw materials |
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