| Company Name: |
cjbscvictory |
| Tel: |
13348960310 13348960310 |
| Email: |
3003867561@qq.com |
Masupirdine free base manufacturers
|
| | Masupirdine free base Basic information |
| Product Name: | Masupirdine free base | | Synonyms: | Masupirdine free base;SUVN-502 free base;1H-Indole, 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-;Masupirdine free base, 10 mM in DMSO;Masupirdine;1-((2-Bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole | | CAS: | 701205-60-9 | | MF: | C21H24BrN3O3S | | MW: | 478.4 | | EINECS: | | | Product Categories: | | | Mol File: | 701205-60-9.mol |  |
| | Masupirdine free base Chemical Properties |
| Boiling point | 613.9±65.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 7.54±0.10(Predicted) |
| | Masupirdine free base Usage And Synthesis |
| Uses | Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1]. | | IC 50 | 5-HT6 Receptor: 2.04 nM (Ki) | | References | [1] Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Po DOI:10.1021/acs.jmedchem.6b01662 |
| | Masupirdine free base Preparation Products And Raw materials |
|